摘要
目的探讨受精第3日发育滞后胚胎冻融胚胎移植(FET)的临床结局。方法回顾性分析2015年1月—2020年3月广州医科大学附属第六医院(清远市人民医院)生殖中心收治的684例FET周期患者的临床资料,根据受精第3日(D3)胚胎卵裂球数目不同分为A组(4~5细胞组)和B组(7~9细胞组)。比较两组胚胎移植后的临床结局。结果A组的临床妊娠率以及活产率低于B组,差异有统计学意义(P<0.05);两组的生化妊娠率、异位妊娠率、流产率、多胎(双胎)妊娠率、活胎分娩的新生儿出生体重比较,差异无统计学意义(P>0.05)。结论移植受精第3日发育滞后胚胎临床妊娠率低于发育速度正常胚胎,但移植后妊娠的患者其临床结局与发育正常胚胎相似,发育滞后的胚胎可作为储备进行冷冻,以减少资源浪费,减轻患者的精神和经济负担。
Objective To investigate the clinical outcome of retarded embryo for frozen-thawed embryo transfer(FET)cycle on fertilization day 3.Methods Retrospective analysis of the clinical data of 684 patients with the cycle FET admitted to Reproductive Center,Guangzhou Medical University Affiliated Sixth Hospital(Qingyuan People′s Hospital)from January 2015 to March 2020 was made,they were divided into group A(4-5 cell group)and group B(7-9 cell group)according to the different number of embryos blastocyst on day 3 of fertilization.Pregnancy outcomes were compared between the two groups.Results The clinical pregnancy rate and live birth rate of the group A were lower than those of the group B,the differences were statistically significant(P<0.05).There were no statistically significant differences in biochemical pregnancy rate,ectopic pregnancy rate,abortion rate and multiple(twin)pregnancy rate as well as the mean birth weight between two groups(P>0.05).Conclusion The clinical pregnancy rate of retarded embryo on fertilization day 3 can is lower than that of normal embryos,but the clinical outcome of pregnant patients after transplantation is similar to that of normal embryos.Retarded embryo can be frozen as a reserve to reduce the waste of resources and the mental and financial burden on patients.
作者
邱佩嫦
陈彩蓉
况玉兰
赵晓英
王秋香
李艳红
陈婉乐
QIU Pei-chang;CHEN Cai-rong;KUANG Yu-lan;ZHAO Xiao-ying;WANG Qiu-xiang;LI Yan-hong;CHEN Wan-le(Reproductive Center,Guangzhou Medical University Affiliated Sixth Hospital(Qingyuan People′s Hospital),Guangdong Province,Qingyuan,511518,China)
出处
《中国当代医药》
CAS
2021年第20期136-139,共4页
China Modern Medicine
关键词
滞后胚胎
冻融胚胎移植
妊娠结局
Retarded embryo
Frozen-thawed embryo transfer
Pregnancy outcomes
