摘要
目的:探讨妊娠早期血红蛋白(Hb)、25-羟维生素D3[25-(OH)VD3]与妊娠期糖尿病(GDM)、分娩方式的关系。方法:收集2019年6月—2020年4月规律产检孕妇1368例,其中GDM组112例,非GDM组1256例,比较2组间年龄、婴儿性别、Hb、体重指数(BMI)、25-(OH)VD3、血压、孕产史、转氨酶、胰岛细胞功能、妊娠指标和分娩方式差异;将P<0.05指标纳入GDM二元Logistic分析,校正混杂因素后,分析Hb、25-(OH)VD3对GDM影响;通过Spearman相关性分析Hb、25-(OH)VD3与GDM、剖宫产的相关性。结果:GDM组、非GDM组间在年龄、BMI、收缩压、舒展压、糖尿病(DM)家族史、25-(OH)VD3、Hb、空腹血糖(GLU)、稳态模型评估的胰岛β细胞功能指数(HOMA-β)、孕期体重增长数、羊水指数、阴道分娩率、剖宫产率方面差异均有统计学意义(均P<0.05);Hb、25-(OH)VD3、收缩压、舒张压、DM家族史、年龄均为GDM影响因素,OR值分别为1.684、0.643、1.226、1.312、2.321、1.347,校正混杂因素后Hb、25-(OH)VD3 OR值分别为1.962、0.533(均P<0.05);Hb与GDM发生、剖宫产呈正相关,r值分别为0.195、0.164,25-(OH)VD3与GDM发生呈负相关,r值分别为-0.214(均P<0.05)。结论:妊娠早期Hb、25-(OH)VD3均为GDM发生影响因素,早期Hb、25-(OH)VD3检测可以对GDM发生和剖宫产进行一定程度的预测。
Objective: To investigate the relationship between hemoglobin(HB), 25 hydroxyvitamin D3[25-(OH) VD3]and gestational diabetes mellitus(GDM), delivery mode. Methods: A total of 1368 pregnant women who underwent regular delivery inspections in our hospital from June 2019 to April 2020 were collected, including 112 cases in the GDM group and 1256 cases in the non-GDM group. The age, infant sex, Hb, body mass index(BMI), 25-(OH) VD3, blood pressure, history of pregnancy and childbirth, transaminase, pancreatic islet cell function, pregnancy indicators and differences in delivery methods between the two groups were compared. The P<0.05 index was included in the GDM binary Logistic analysis. After adjusting for confounding factors, the impact of Hb and 25-(OH) VD3 on GDM was analyzed. The correlation of Hb and 25-(OH) VD3 with GDM and cesarean section was analyzed by Spearman correlation analysis. Results: There were significant differences in age, BMI, systolic blood pressure, diastolic blood pressure, family history of diabetes mellitus(DM), 25-(OH) VD3, Hb, fasting blood glucose(Glu), HOMA-βcell function index(HOMA-β), weight gain during pregnancy, amniotic fluid index, vaginal delivery rate and cesarean section rate between GDM group and non GDM group(all P<0.05). Hb, 25-(OH) VD3, systolic blood pressure, diastolic blood pressure, family history of DM and age were all influencing factors of GDM, and OR values were 1.684, 0.643, 1.226, 1.312, 2.321 and 1.347, respectively. After adjusting for confounding factors, OR values of Hb and 25-(OH) VD3 were 1.962 and 0.533(both P<0.05). Hb was positively correlated with the occurrence of GDM and cesarean section with r values of 0.195 and 0.164, and 25-(OH) VD3 was negatively correlated with the occurrence of GDM and cesarean section with r values of-0.214(P<0.05). Conclusion: Hb and 25-(OH) VD3 in early pregnancy mgiht be all influencing factors of GDM. Early detection of Hb and 25-(OH) VD3 could predict the occurrence of GDM and cesarean section to a certain extent.
作者
陈婧
赵英俊
陈燕萍
陈慧
CHEN Jing;ZHAO Yingjun;CHEN Yanping;CHEN Hui(Department of Obstetrics and Gynecology,No.909 Hospital of Joint Logistics Support Force,Zhangzhou,363000,China;Department of Blood Transfusion,No.909 Hospital of Joint Logistics Support Force)
出处
《临床血液学杂志》
CAS
2021年第6期407-411,共5页
Journal of Clinical Hematology
关键词
妊娠期糖尿病
血红蛋白
25-羟维生素D3
剖宫产
不良妊娠结局
gestational diabetes mellitus
hemoglobin
25-hydroxyvitamin D3
cesarean section
adverse pregnancy outcomes
