摘要
目的检测鸢尾素、25-羟基维生素D在妊娠期糖尿病孕妇血清中的临床意义。方法随机选取2022年2月—9月在厦门市第五医院进行产检的孕妇317例,所有病例均在孕24~28周行75 g葡萄糖耐量试验(OGTT),登记患者的一般资料,OGTT结果异常的153例为GDM组,OGTT结果正常的164例为对照组。采用ELISA检测两组病例血清鸢尾素、25-羟基维生素D水平,同时检测糖脂代谢指标,计算胰岛素抵抗。比较两组之间各指标的差异,采用多因素逻辑回归分析法分析GDM的危险因素,探讨两个因子在GDM中的临床价值。结果两组血清鸢尾素、25-羟基维生素D水平差异均P<0.01;多因素Logistic回归分析法分析GDM的危险因素,25-羟基维生素D是保护性因素(OR 0.262,95%CI 0.080~0.856,P=0.027);血清鸢尾素是保护因素(OR 0.001,95%CI 0.000~0.010,P<0.01)。结论鸢尾素和25-羟基维生素D在GDM孕妇血清中呈低水平表达;鸢尾素、25-羟基维生素D可能是GDM的保护性因素。
Objective To detect the clinical significance of irisin and 25-hydroxyvitamin D in serum of pregnant women with gestational diabetes mellitus(GDM).Methods A total of 317 pregnant women who underwent antenatal check-up in Xiamen Fifth Hospital from February to September 2022 were randomly selected.All cases underwent 75 g glucose tolerance test(OGTT)at 24-28 weeks of gestation.General data of registered patients showed that 153 cases with abnormal OGTT results were GDM group.The control group consisted of 164 patients with normal OGTT results.Serum levels of irisin and 25-hydroxyvitamin D were detected by ELISA,and glucose and lipid metabolism indexes were detected to calculate insulin resistance.The risk factors of GDM were analyzed by multi-factor logistic regression analysis,and the clinical value of the two factors in GDM was discussed.Results The levels of serum irisin and 25-hydroxyvitamin D were different between the two groups(P<0.01).Multiple Logistic regression analysis showed that 25-hydroxyvitamin D was a protective factor(OR 0.262,95%CI 0.080-0856,P=0.027);Serum irisin was a protective factor(OR 0.001,95%CI 0.000-0.010,P<0.01).Conclusions The expression of irisin and 25-hydroxyvitamin D in serum of pregnant women with GDM is low.Irisin and 25-hydroxyvitamin D may be protective factors of GDM.
作者
汤浩文
周岩
王小娥
TANG Haowen;ZHOU Yan;WANG Xiaoe(Xiamen Fifth Hospital,Xiamen 361100,China;The Second Affiliated Hospital of Shandong First Medical University,Tai'an 271000,China)
出处
《中国医药指南》
2024年第6期27-30,共4页
Guide of China Medicine
