摘要
目的运用血栓弹力图(TEG)联合凝血功能分析妊娠高血压综合征(PIH)的凝血特点,探求其临床意义。方法选取2018年12月到2019年9月我院产科收治的孕28周及临产前孕妇,47例妊娠高血压综合征患者,其中初产妇36例,经产妇11例;年龄21~40岁,平均(27.3±4.1)岁;分为妊娠高血压(PIH)组34例,子痫组13例作为研究组。同时选取40例年龄匹配的正常妊娠者作为对照组,其中初产妇25例,经产妇15例;年龄22~37岁,平均(26.9±3.6)岁。观察3组患者TEG和凝血功能指标,并进行分析研究。结果妊娠高血压组(PIH)、子痫组患者R值、K值均较对照组明显减小,MA值与α角较对照组增高,有统计学差异(P<0.05)。PIH组与子痫组除R值外,其余均有差异(P<0.05);PIH组与子痫组除TT外,PT、APTT均较对照组有所缩短,FIB与D-二聚体有明显增高均有统计学差异。PIH组与子痫组PT、APTT、TT未见明显差异(P>0.05),FIB、D-二聚体比较差异有统计学意义(P<0.05)。结论通过TEG和凝血指标的监测,能够反映妊娠高血压综合征患者的凝血状况,并与其疾病进展有一定的相关性,值得临床推广应用。
Objective The thrombus elasticity map(TEG)combined with coagulation function was used to analyze the coagulation characteristics of pregnancy-induced hypertension syndrome(PIH),and its clinical significance was explored.Methods From December 2018 to September 2019,47 pregnant women with pregnancy induced hypertension syndrome were selected from our hospital,including 36 primiparas and 11 primiparas.The patients were 21-40 years old,with an average age of(27.3±4.1)years old.They were divided into pregnancy induced hypertension(PIH)group(34 cases)and eclampsia group(13 cases)as the study group.At the same time,40 age matched normal pregnant women were selected as the control group,including 25 primiparas and 15 primiparas,The patients were 22-37 years old with an average age of(26.9±3.6)years old.The TEG and coagulation indexes of three groups were observed and analyzed.Results The R value and K value of PIH and eclampsia group were significantly lower than those of the control group,and MA value andαangle were significantly higher than those of the control group(P<0.05).Except for R value,there were differences between PIH group and eclampsia group(P<0.05);except TT,PT and APTT in PIH group and eclampsia group were shorter than those in control group,FIB and D-dimer were significantly higher than those in control group.There was no significant difference in Pt,APTT and TT between PIH group and eclampsia group(P>0.05).There was significant difference in FIB and D-dimer(P<0.05).Conclusion Through the monitoring of TEG and coagulation index,it can reflect the coagulation status of patients with pregnancy induced hypertension,and has a certain correlation with the disease progress,which is worthy of clinical application.
作者
苏小梅
周鹏
罗琳
SU Xiaomei;ZHOU Peng;LUO Lin(Shangrao municipal hospital Clinical laboratory,Shangrao 334000,China.)
出处
《实验与检验医学》
CAS
2021年第3期538-539,551,共3页
Experimental and Laboratory Medicine
关键词
血栓弹力图
凝血功能
妊娠高血压综合征
Thromboelastogram
Coagulation function
pregnancy-induced hypertension syndrome
