摘要
T-2毒素作为粮食作物的主要污染物,对人和动物的消化系统、神经系统、生殖发育等都存在毒性作用。在我国大骨节病病区,大骨节病发生的病因物质是病区产谷物内超常聚集的T-2毒素。通过改变生产生活方式、换粮等综合防治措施,大骨节病防治成果显著,但病区外环境中仍有致病因子存在。本文在T-2毒素代谢动力学方面,将相关研究文献进行综述,阐述了T-2毒素的理化性质、体内分布、代谢动力学、生物转化以及T-2毒素及其代谢产物对各脏器的损伤,以期为T-2毒素对全身各器官影响研究提供新的思考。
As the main pollutant of food crops,T-2 toxin has toxic effects on human and animal digestive system,nervous system,reproductive development and so on.In Kashin-Beck disease related areas in China,the etiological substance of Kashin-Beck disease is the abnormal accumulation of T-2 toxin in the grain produced in the endemic area.The prevention and treatment of Kashin-Beck disease has achieved remarkable results through the comprehensive prevention and control measures,such as changing the production and life style,grain exchange,etc.,but there are still pathogenic factors in the external environment of the disease area.In this paper,the metabolic kinetics of T-2 toxin is reviewed,and the physicochemical properties,distribution in the body,metabolic kinetics,biotransformation and damage of T-2 toxin and its metabolites to various organs are described,so as to provide new thinking for the study on the effects of T-2 toxin on various organs of the body.
作者
李春辉(综述)
崔丝露(审校)
Li Chunhui;Cui Silu(Institute for Kaschin-Beck Disease Control,Center for Endemic Disease Control,Chinese Center for Disease Control and Prevention,Harbin Medical University,Harbin 150081,China)
出处
《中华地方病学杂志》
CAS
北大核心
2021年第7期599-602,共4页
Chinese Journal of Endemiology
基金
2018年度黑龙江省省属高等学校基本科研业务费科研项目。
