摘要
胚胎致死性异常视觉样蛋白1(ELAVL1/HuR)是一种RNA结合蛋白,通过与特定的mRNA结合参与转录后调控,从而影响细胞增殖、凋亡、分化等生物学行为。近年来研究表明,ELAVL1与肿瘤细胞的增殖、血管生成、侵袭、转移及耐药性明显相关。本文就ELAVL1蛋白与肿瘤进展关系展开综述。
ELAVL1/HuR is a kind of RNA-binding protein,which belongs to a member of the embryonic lethal abnormal vision(ELAV)family.It selectively stabilizes particular mRNAs and involves in post-transcriptional regulation to mediate a variety of cell behaviors including proliferation,apoptosis,and differentiation.Recent studies show that ELAVL1 is closely related to tumor proliferation,neoangiogenesis,invasion,metastasis,and resistance to cancer therapy.This review gives an overview on the relationship between ELAVL1 and tumor progression.
作者
陈禹鑫
殷文婕
蒋壮
徐彤
许之阳
周永平
戴途
王浩
Yu-xin Chen;Wen-jie Yin;Zhuang Jiang;Tong Xu;Zhi-yang Xu;Yong-ping Zhou;Tu Dai;HaoWang(Department of Clinical Medicine,The First Clinical Medical College of Nanjing Medical University,Nanjing,Jiangsu 210029,China;Department of Clinical Medicine,Medical School of Nantong University,Nantong,Jiangsu 226019,China;Nanjing Medical University Affiliated Wuxi Second Hospital(Wuxi Clinical College affiliated to Nantong University),Wuxi,Jiangsu 214002,China)
出处
《中国现代医学杂志》
CAS
北大核心
2021年第13期65-70,共6页
China Journal of Modern Medicine
基金
江苏省无锡市卫健委青年项目(No:Q201824)
南通大学临床医学专项(No:2019JZ022)。
