摘要
目的对天津市某社区老年健康体检人群增加尿白蛋白、尿肌酐和血尿酸定量检测,调查慢性肾脏病(chronic kidney disease,CKD)的流行现况及影响因素,为其早期防治和社区管理提供依据。方法选取2019年4-7月在天津市东丽区军粮城医院参加免费查体的60岁及以上老年居民6 685例,收集体检资料,增加尿白蛋白、尿肌酐和血尿酸的检测,计算尿白蛋白2/肌酐比值(albumin to creatinineratio,ACR)。采用χ检验进行计数资料比较,采用非条件logistic回归模型分析CKD的影响因素。结果在5 288例资料完整的老年人群中,CKD总患病率为32.68%。应用ACR可在肾功能下降早期阶段筛查出26.88%的老年CKD患者。多因素logistic回归分析显示,女性、年龄、SBP≥140 mmHg、FPG≥6.1 mmol/L、高尿酸血症及低HDL-C血症是CKD的独立危险因素。结论该社区老年人群CKD患病率较高,在免费体检时增加尿白蛋白和尿肌酐检测可提高肾功能下降早期阶段的CKD检出率,增加血尿酸检测有助于CKD危险防控;SBP、FPG、SUA及HDL-C水平异常者更需加强CKD的早期防控。
Objective To investigate the prevalence and influencing factors of chronic kidney disease(CKD)among older adults participated in health check-up in a community of Tianjin in tests of urinary albumin,urine creatinine and serum uric acid,so as to for early prevention,control and management of CKD.Methods A total of 6685 elderly residents aged 60 and above who underwent free health examination carried out by Junliangcheng Hospital of Dongli District in Tianjin from April to July 2019 were selected.The health examination data were collected,and the detection of urinary albumin,urine creatinine and serum uric acid was included.The albumin to creatinine ratio(ACR)was calculated.The count data were statistically analyzed by chi-square test,and the unconditional logistic regression model was used to analyze the influencing factors of CKD.Results Among 5288 subjects with complete data,the total prevalence of CKD was 32.68%.Application of ACR was able to detect 26.88%of CKD patients at the early stage of renal dysfunction in the elderly.Multivariate logistic regression analysis showed that the influencing factors of CKD including females,age,SBP≥140 mmHg,FPG≥6.1 mmol/L,hyperuricemia and low HDL-Cemia.Conclusion The prevalence of CKD in community-dwelling elderly in Tianjin is relatively high.The detection rate of CKD in the early stage of renal dysfunction can be improved by the tests of urinary albumin and creatinine in health check-up for the elderly.Adding serum uric acid test will contribute to the prevention and control of CKD.The early prevention and control of CKD should be strengthened when people with abnormal levels of SBP,FPG,SUA and HDL-C.
作者
陈如萍
刘蕊
孙遨
曹玉洁
周晓杰
张莎
CHEN Ruping;LIU Rui;SUN Ao;CAO Yujie;ZHOU Xiaojie;ZHANG Sha(Graduate School of Tianjin Medical University,Tianjin 300070,China;Department of Clinical Laboratory,Tianjin Union Medical Centre,Tianjin 300121,China)
出处
《实用医学杂志》
CAS
北大核心
2021年第13期1755-1760,共6页
The Journal of Practical Medicine
基金
天津市人民医院院级课题(编号:2020YJ019)。
关键词
慢性肾脏病
影响因素
尿白蛋白
血尿酸
老年人
社区
chronic kidney disease
influencing factors
urinary albumin
serum uric acid
older adults
community
