摘要
目的探讨18氟-标记脱氧葡萄糖正电子发射断层摄影(^(18)F-FDG/PET-CT)在前列腺癌中的应用价值。方法回顾性分析本院2017年4月至2018年3月前列腺病变60例患者临床资料,分析^(18)F-FDG/PET-CT在前列腺癌中的诊断价值。结果^(18)F-FDG/PET-CT对前列腺病灶良恶性诊断灵敏度为87.88%,特异度为81.48%,准确度为85.00%,阳性预测值为85.29%,阴性预测值为84.62%;前列腺增生与前列腺癌患者非靶组织最高标准摄取值(SUVmax)比较,差异无统计学意义(P>0.05);前列腺癌患者靶组织SUVmax以及前列腺病灶和肌肉组织SUVmax比值(P/M)高于前列腺增生患者,差异有统计学意义(P<0.05);以所有前列腺病变患者P/M值绘制ROC曲线,通过ROC分析评价P/M判断前列腺癌可靠性,结果显示曲线下AUC=0.852[95%CI(0.756~0.948)],寻找最佳截点P/M值为8.60,此时灵敏度为81.80%,特异度为81.50%;前列腺癌不同分期P/M值比较,差异无统计学意义(P>0.05);经病理诊断33例乳腺癌患者中共有17例伴淋巴结转移,^(18)F-FDG/PET-CT检测出淋巴结转移15例,准确性为88.23%。结论^(18)F-FDG/PET-CT判断前列腺病变良恶性效能高,对于转移灶检出率较高,有利于指导临床确定合理的治疗方案。
Objective To explore the application value of^(18)F-fluorodeoxyglucose-positron emission tomography(^(18)F-FDG/PET-CT)in prostate cancer.Methods The clinical data of 60 patients with prostate lesions from April 2017 to March 2018 in our hospital were retrospectively analyzed.The diagnostic value of^(18)F-FDG/PET-CT in prostate cancer was analyzed.Results The sensitivity,specificity,accuracy,positive predictive value,and negative predictive value of^(18)F-FDG/PET-CT in diagnosising benign and malignant prostate lesions were 87.88%,81.48%,85.00%,85.29%,and 84.62%.There was no significant difference in the maximum standard uptake value(SUVmax)of non-target tissues between patients with benign prostatic hyperplasia and patients with prostate cancer(P>0.05).The SUVmax of target tissues and the SUVmax ratio of prostate lesions and muscle tissues(P/M)in patients with prostate cancer were higher than those in patients with benign prostatic hyperplasia(P<0.05).ROC curve was drawn from P/M values of all patients with prostate lesions,and the reliability of P/M in evaluating the prostate cancer by ROC analysis showed AUC under curve was 0.852[95%CI(0.756-0.948)],and the best cut-point P/M value was 8.60,and the sensitivity and specificity were 81.80%and 81.50%.There was no statistically significant difference in the P/M value of different stages of prostate cancer(P>0.05).A total of 17 cases of lymph node metastasis among 33 breast cancer patients by pathological diagnosis,and 18 cases of lymph node metastasis were detected by^(18)F-FDG/PET-CT with an accuracy of 88.23%.Conclusions^(18)F-FDG/PET-CT has high efficacy in judging the benign and malignant prostate lesions,and it has high detection rate of metastases,and it is helpful to guide the clinical determination of reasonable treatment methods.
作者
田姣
李转
杨丹
杜冬艳
侯敏
赵钰
李智斌
TIAN Jiao;LI Zhuan;YANG Dan;DU Dong-yan;HOU Min;ZHAO Yu;LI Zhi-bin(Department of Urology,the First Affiliated Hospital of Air Force Military University,Xi'an 710032,Shaanxi Province,China)
出处
《中国CT和MRI杂志》
2021年第8期117-119,125,共4页
Chinese Journal of CT and MRI
基金
陕西省科技重点项目(2018PT-11)。
