摘要
目的探讨贵阳地区40岁及以上人群中促甲状腺激素(TSH)正常水平与短期心血管事件发病率的关系。方法选取贵阳市云岩区40岁及以上年龄、且血清TSH水平在正常范围内的居民7445人,分为第1组(TSH 0.550~1.499 mU/L,1241人)、第2组(TSH 1.500~2.499 mU/L,2553人)、第3组(TSH 2.500~3.499 mU/L,2118人)及第4组(TSH 3.500~4.780 mU/L,1533人),收集4组居民随访前(基线)的一般情况[性别、年龄、收缩压(SBP)、舒张压(DBP)等],统一仪器测量身高、体质量、腰围并计算体质量指数(BMI);采集空腹静脉血5 mL,2 mL用于检测血糖(FBG),2 mL分离血清后检测高密度脂蛋白(HDL-c)、低密度脂蛋白(LDL-c)、甘油三酯(TG)及总胆固醇(TC),1 mL分离血清后检测血清TSH水平,同时记录4组居民心血管事件(冠心病、心肌梗死、心力衰竭)和脑血管事件(脑出血、脑梗死)发生情况;随访2.97~3.17年,收集4组居民中首次发生心脑血管事件和因首次心脑血管事件而死亡情况,采用Logistic回归分析参考范围内TSH水平对心脑血管事件发病率的影响。结果4组随访居民女性构成、TC、TG及LDL-c水平的差异有统计学意义(P<0.05);4组随访居民标化后心脑血管事件发病率分别为2.13%、2.32%、2.62%及3.01%,差异无统计学意义(P>0.05);Logistic线性回归分析结果表明,TSH水平不是短期心脑血管事件发病率的影响因素(P>0.05)。结论贵阳地区40岁及以上TSH不同参考值水平人群的短期心血管事件发病率相似,未发现降低TSH参考范围上限值对降低心血管事件短期发病率有益的证据。
Objective To investigate the relationship between normal thyroid-stimulating hormone(TSH)levels and the incidence of short-term cardiovascular events in Guiyang residents aged 40 years old and above.Methods A total of 7445 residents(≥40 years old)with normal serum TSH levels were recruited in Yunyan district of Guiyang.Based on serum TSH levels,these residents were divided into the first group(TSH 0.550-1.499 mU/L,n=1241),the second group(TSH 1.500-2.499 mU/L,n=2553),the third group(TSH 2.500-3.499 mU/L,n=2118)and the fourth group 4(TSH 3.500-4.780 mU/L,n=1533).Before follow-up,general information(baseline)including gender,age,systolic blood pressure(SBP),diastolic blood pressure(DBP)were collected.Body height,body weight,and waist circumference were measured using the same model of height/weight instrument.Body mass index(BMI)was calculated.Fasting venous blood(5 mL)was collected,among which,2 mL used for detecting fasting blood glucose(FBG),2 mL for isolating the serum to detect high-density lipoprotein(HDL-c),low-density lipoprotein(LDL-c),triglycerides(TG),and total cholesterol(TC),1 mL for isolating serum to detect TSH levels.Additionally,cardiovascular events(coronary heart disease,myocardial infarction,heart failure)and cerebrovascular events(cerebral hemorrhage,cerebral infarction)were recorded at the same time.During follow-up visits lasting 2.97 to 3.17 years,the first cardiovascular/cerebrovascular events,and deaths due to the first cardiovascular/cerebrovascular events were collected.Logistic regression was applied to analyze the impact of TSH levels within the reference range on the incidences of cardiovascular/cerebrovascular events.Results The differences in female composition,TC,TG,and LDL-c levels among the four groups were statistically significant(P<0.05).The incidences of cardiovascular and cerebrovascular events after standardization in four groups were 2.13%,2.32%,2.62%,and 3.01%,respectively(P>0.05).Logistic linear regression analysis revealed that TSH level is not a factor influencing th
作者
孙迪可
彭年春
张淼
张巧
时立新
SUN Dike;PENG Nianchun;ZHANG Miao;ZHANG Qiao;SHI Lixin(Department of Endocrine and Metabolic Diseases,the Affiliated Hospital of Guizhou Medical University,Guiyang 550004,Guizhou,China)
出处
《贵州医科大学学报》
CAS
2021年第7期786-791,共6页
Journal of Guizhou Medical University
基金
科技部国家重点研发计划精准医学专项(2016YFC0901203)
国家卫生和计划生育委员会公益性行业科研专项(201502007)
2016年贵州省临床重点专科培育项目(医政SZD-2016-01)。
关键词
参考值
心血管疾病
发病率
队列研究
促甲状腺激素
正常范围
脑血管疾病
reference values
cardiovascular diseases
incidence
cohort studies
thyroid-stimulating hormone(TSH)
normal range
cerebrovascular disease
