摘要
目的:观察活血退黄汤加减对婴儿胆汁淤积性肝病临床症状、肝功能及炎症因子的影响。方法:选取胆汁淤积性肝病婴儿94例,按随机数字表法分为对照组和观察组各47例。对照组给予常规西药治疗,观察组在对照组基础上给予活血退黄汤加减治疗。比较2组临床疗效,统计2组治疗前后中医证候积分,检测2组治疗前后肝功能指标[总胆汁酸(TBA)、直接胆红素(DBil)、总胆红素(TBil)]及炎症因子水平[白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]。比较2组治疗前后肝脏、脾脏大小及治疗期间不良反应发生情况。结果:观察组总有效率为91.49%,高于对照组76.60%,差异有统计学意义(P<0.05)。治疗前,2组中医证候积分比较,差异无统计学意义(P>0.05)。治疗后,2组中医证候积分较治疗前降低,且观察组中医证候积分低于对照组,差异有统计学意义(P<0.05)。治疗前,2组TBA、DBil、TBil、IL-6、TNF-α水平比较,差异无统计学意义(P>0.05)。治疗后,2组TBA、DBil、TBil、IL-6、TNF-α水平较治疗前降低,且观察组DBil、TBil、IL-6、TNF-α水平低于对照组,差异均有统计学意义(P<0.05)。治疗前,2组肝脏、脾脏大小比较,差异无统计学意义(P>0.05)。治疗后,2组肝脏、脾脏均较治疗前缩小,且观察组肝脏、脾脏均小于对照组,差异均有统计学意义(P<0.05)。观察组不良反应发生率为4.26%,对照组为2.13%,2组比较,差异无统计学意义(χ2=0.344,P=0.557)。结论:活血退黄汤加减治疗婴儿胆汁淤积性肝病能缓解临床症状,改善肝功能,减轻炎症反应。
Objective:To observe the effect of modified Huoxue Tuihuang tang on clinical symptoms,liver function and inflammatory factors of infants with cholestatic liver disease.Methods:A total of 94 cases of infants with cholestatic liver disease were divided into the control group and the observation group according to the random number table method,47 cases in each group.The control group was treated with routine western medicine,and the observation group was additionally treated with modified Huoxue Tuihuang tang based on the treatment of the control group.The clinical effect and the incidences of adverse reactions in the two groups were compared.Before and after treatment,Chinese medicine syndrome scores in the two groups were counted;liver function indexes including total bile acid(TBA),direct bilirubin(DBil)and total bilirubin(TBil)as well as the levels of inflammatory factors including interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)in the two groups were detected;the sizes of liver and spleen in the two groups were compared.Results:The total effective rate was 91.49%in the observation group,higher than that of 76.60%in the control group,the difference being significant(P<0.05).Before treatment,there was no significant difference being found in the comparison of Chinese medicine syndrome scores between the two groups(P>0.05).After treatment,Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment,and the score in the observation group was lower than that in the control group,the difference being significant(P<0.05).Before treatment,there were no significant difference being found in the comparison of the levels of TBA,DBil,TBil,IL-6 and TNF-αbetween the two groups(P>0.05).After treatment,the levels of TBA,DBil,TBil,IL-6 and TNF-αin the two groups were decreased when compared with those before treatment,and the levels of DBil,TBil,IL-6 and TNF-αin the observation group were lower than those in the control group,differences being significant(P<0.05).Before
出处
《新中医》
CAS
2021年第12期121-125,共5页
New Chinese Medicine
关键词
胆汁淤积性肝病
婴儿
活血退黄汤
肝功能
中医证候积分
炎症因子
Cholestatic liver disease
Infants
Huoxue Tuihuang tang
Liver function
Chinese medicine syndrome scores
Inflammatory factors
