摘要
Objectives:Our study aimed to investigate the prevalence of cognitive impairment(CI)and the associated risk factors among elderly people in Shanghai urban area,China.Methods:A population-based survey was conducted among people aged 55 years or older in urban areas of Shanghai.Face-to-face interviews were carried out to collect information including demographic characteristics,medical history,and medication use,etc.The validated Chinese version of the Mini-Mental State Examination(MMSE)was used to screen subjects with CI,and the criteria of CI were adjusted for education levels.Results:A total of 3,176 home-living residents(≥55 years old)were included in the study.Among them,266 people(102 men and 164 women)were identified as cognition impaired,with a prevalence of 8.38%(266/3,176,95%CI:(8.26,8.49))for both genders,9.21%(102/1,107,95%CI:(9.18,9.33))for men and 7.93%(164/2,069,95%CI:(7.80,8.09))for women,respectively.Furthermore,we found that several significant risk factors,including social factors(education,number of children,marriage status,and family structure),physiological factors(age,blood glucose level,and obesity),factors on living styles(physical exercise,diet&chronic diseases),and genetic factor(ApoE),associated with CI onset.Conclusions:This study confirms the high prevalence of CI among the elderly population in the Shanghai urban in China,similar to previous epidemiologic studies in Western countries.The putative risk factors associated with CI merit further investigated.
基金
This study was supported by the National Basic Research Development Program of China(No.2010CB945200)
Shanghai Key Discipline Program(No.S30202)
Shanghai Key Project of Basic Science Research(No.09DZ1950400)
Shanghai Natural Scientific Fund(No.09JC1416402,09ZR1419100)
Program for Outstanding Medical Academic Leader(No.LJ 06003)
Shanghai Jiao Tong University Medical and Engineering Joint Key Project(No.YG2010ZD102)
Sincere gratitude should also be extended to all of graduate students,doctors,nurses as well as those social workers in the communities who were involved in the study.Without their effort this paper would not come into being.
