摘要
目的研究解毒活血健脾方在大肠腺瘤息肉患者术后的应用效果。方法选取2019年8月至2020年2月于深圳市宝安区中医院接受诊治的86例中老年大肠腺瘤性息肉患者,按照随机数字表法分为对照组和观察组,各43例。两组患者均行内镜下黏膜切除术,术后给予对照组患者营养支持、抗感染等常规治疗,观察组患者在对照组的基础上使用中医药解毒活血健脾方治疗,比较两组患者临床疗效,术前、术后2个月中医证候积分评分、血清白介素-18(IL-18)、白介素-17(IL-17)、白介素-1β(IL-1β)水平,以及术后6个月复发情况。结果观察组患者临床总有效率高于对照组;与术前比,术后2个月两组患者腹部疼痛、食少纳呆、体倦乏力、大便溏烂、肛门灼热、里急后重等中医症候积分与血清IL-18、IL-17、IL-1β水平均降低,且观察组低于对照组;术后6个月,观察组患者复发率低于对照组(均P<0.05)。结论中老年大肠腺瘤性息肉患者术后予以中药解毒活血健脾方干预治疗,可降低术后复发率,减轻炎症反应,临床效果确切。
Objective To study the application effect of Jiedu Huoxue Jianpifang on patients with colorectal adenoma polyp after operation. Methods A total of 86 middle-aged and old patients with adenomatous polyps in the colon who received diagnosis and treatment in Shenzhen Bao ’an District Traditional Chinese Medicine Hospital from August 2019 to February 2020 were selected, all patients underwent endoscopic mucosal resection, according to random number table method they were divided into control group(43 patients, give nutrition support, anti-infection) and the observation group(43 patients, on the basis of the control group, using Jieduhuoxuejianpifang for treatment), patients in both groups were treated for 2 months, the clinical efficacy of the two groups of patients after postoperation, TCM syndrome score, serum interleukin-18(IL-18), interleukin-17(IL-17), interleukinIL-1β(IL-1β) levels preoperative and 2 months postoperative and recurrence 6 months after postoperation. Results The total effective rate of observation group was higher than the control group;Compared with preoperation, the scores of abdominal pain, poor appetite, fatigue, loose stools, burning anus, tenesmus and the serum levels of IL-18, IL-17 and IL-1β of the two groups 2 months after operation decreased, and the observation group was lower than the control group;After 6 months postoperation, the recurrence rate of observation group was lower than the control group(all P < 0.05). Conclusion Middle-aged and old patients with adenomatous polyps of the large intestine were given Chinese medicine Jiedu huoxue jianpifang for postoperative intervention treatment, which can reduce postoperative recurrence rate, reduce inflammatory reaction, and the clinical effect is exact.
作者
谢建军
XIE Jianjun(Endoscope Department,Shenzhen Bao’an District Traditional Chinese Medicine Hospital,Shenzhen,Guangdong 518105,China)
基金
2019年宝安区医疗卫生基础研究项目(编号:2019JD348)。
关键词
解毒活血健脾方
大肠腺瘤性息肉
内镜下黏膜切除术
炎性因子
Jiedu huoxue jianpifang
Colorectal adenoma polyps
Endoscopic mucosal resection
Inflammatory factors
