摘要
目的探讨理想心血管行为因素对新发颈动脉内中膜厚度(CIMT)增厚的影响。方法参加开滦2016年度健康体检人群填写全部7项心血管健康行为因素后行心血管健康评分(CHS),并于2016年度及2019年度分别进行颈动脉超声检查,选取其中2016年度CIMT正常及2019年度(较2016年度)CIMT增厚者数据,根据2016年度CHS的三分位进行分组,采用方差分析、卡方检验及多因素Logistic回归模型分析各CHS分位组对新发CIMT增厚的影响,以P<0.05(双侧检验)为差异有统计学意义。结果 2016年度健康体检指标完整且首次CIMT正常者3006例,依据纳入及排除标准筛选最终纳入统计分析为2964例,平均年龄为(51.32±9.03)岁,男性1533例(51.72%),随访时间为(2.41±0.54)年。平均CHS为(8.69±2.21)分,根据CHS分组:第一分位组(880例):CHS≤7;第二分位组(952例):7<CHS≤9;第三分位组(1132例):CHS>9。经过2.41年的随访,新发CIMT增厚者538例(18.05%),新发CIMT增厚率随着CHS水平的增加而降低(P<0.001)。经多因素Logistic回归分析,与CHS第一分位组相比,第二、三分位组新发CIMT增厚的OR值(95%CI)分别是0.76(0.59~0.98)、0.54(0.41~0.71)。CHS每增加1分,发生新发CIMT增厚的OR值(95%CI)是0.89(0.84~0.94)。结论 CHS较高者新发CIMT增厚的机率明显减低,理想心血管健康行为与亚临床动脉粥样硬化的低风险有关,可预防心血管疾病的发生。
Objective To discuss the influence of factors of ideal cardiovascular behavioral(CVH)on new-onset thickening of carotid artery intima-media thickness(CIMT).Methods The people with physical examinations,took part in physical examination in 2016,all completed 7-item survey of cardiovascular health factors and then received grading of cardiovascular health scores(CHS).All people had carotid ultrasound examination in 2016 and 2019,respectively.The data was collected from people with normal CIMT in 2016 and those with CIMT thickening in 2019(compared with that in 2016),and grouped according to CHS in 2016.The influence of CHS on new-onset CIMT thickening was analyzed by using analysis of variance(ANOVA),chi-square test and multi-factor Logistic regression model taken P<0.05(bilateral test)as difference had statistical significance.Results There were 3006 cases with complete health examination materials and normal CIMT in 2016,and finally 2964 included statistical analysis according to inclusion and exclusion criteria.The average age was(51.32±9.03)year old.There were 1533 male cases(51.72%).The follow-up time was(2.41±0.54)y.The CHS scores were(8.69±2.21)averagely.After grouped according to CHS,all cases were divided into group 1(n=880,CHS≤7),group 2(n=952,7<CHS≤9)and group 3(n=1132,CHS>9).The results of 2.41-y follow-up showed that there were 538 cases(18.05%)with new-onset CIMT thickening.The incidence rate of new-onset CIMT thickening decreased along with CHS increased(P<0.001).The results of multi-factor Logistic regression showed that,compared with group 1,CHS was significantly correlated to new-onset CIMT thickening(R=0.76,95%CI:0.59~0.98 in group 2,R=0.54,95%CI:0.41~0.71 in group 3).For each increased 1 score of CHS,OR value of new-onset CIMT thickening incidence was 0.89(95%CI:0.84~0.94).Conclusion The people with higher CHS have decreased incidence rate of new-onset CIMT thickening,and ideal CVH is related to low risk of subclinical atherosclerosis,which can prevent cardiovascular disease.
作者
张莹
杜鑫
李劼
马琳
张树华
吴寿岭
Zhang Ying;Du Xin;Li Jie;Ma Lin;Zhang Shuhua;Wu Shouling(Department of Ultrasonography,Affiliated Hospital of North China University of Technology,Tangshan 063000,China)
出处
《中国循证心血管医学杂志》
2021年第7期858-861,共4页
Chinese Journal of Evidence-Based Cardiovascular Medicine
关键词
理想心血管行为和因素
心血管健康评分
颈动脉内中膜厚度
心血管疾病
Ideal cardiovascular behavioral factors
Cardiovascular health scores
Carotid intima-media thickness
Cardiovascular diseases
