摘要
目的探讨高校退休教职工血尿酸水平与颈动脉粥样硬化相关性。方法选取2016-01～2016-06于北京交通大学社区卫生服务中心参加常规体检的我校914例退休教职工,进行标准的问卷调查及血尿酸和颈动脉彩超检查,分析其颈动脉超声情况,根据血尿酸水平分为高尿酸血症组和血尿酸正常组。高尿酸血症组共463例,平均年龄为(68. 62±10. 47)岁,血尿酸正常组共451例,平均年龄(67. 34±10. 18)岁。比较两组一般资料,比较两组颈动脉粥样硬化情况,分析高尿酸血症不同合并症颈动脉粥样硬化情况。结果高尿酸血症组人群与血尿酸正常组人群的年龄、体质量指数、吸烟和饮酒所占比例、运动频次均无明显差异(P> 0. 05),同时也发现高尿酸血症人群血糖、血脂水平明显高于血尿酸正常人群(P <0. 05),高尿酸血症组IMT增厚、颈动脉双侧均有斑块、颈动脉狭窄、硬斑所占比例显著高于血尿酸正常组(P <0. 05),高尿酸血症合并脑卒中组与高尿酸血症合并高血压组的IMT增厚、双侧斑块、硬斑块和颈动脉狭窄所占比例高于高尿酸血症合并糖尿病组和高尿酸血症合并冠心病组(P <0. 05)。结论高校退休教职工高尿酸血症人群IMT增厚、颈动脉双侧斑块和狭窄比例明显高于血尿酸正常人群,且需重点关注高尿酸血症合并脑卒中与高尿酸血症合并高血压人群颈动脉斑块情况,制定相关防治措施。
Objective To explore the relationship between serum uric acid level and carotid atherosclerosis of retired faculty members from a university.Methods From January to June2016,914retired faculty members from a university were enrolled in routine physical examination in the Community Health Service Center of Beijing Jiaotong University.Standard questionnaire was conducted,and blood uric acid and carotid ultrasound examinations were observed.According to the level of serum uric acid,the patients were divided into hyperuricemia group and normal blood uric acid group.There were463patients in hyperuricemia group with an average age of(68.62±10.47)years,and451patients in normal blood uric acid group with an average age of(67.34±10.18)years.The general data and carotid atherosclerosis were compared between the two groups.The carotid atherosclerosis of hyperuricemia patients with different comorbidities was analyzed.Results There was no significant difference in age,body mass index,proportion of smoking and drinking,and frequency of exercise between hyperuricemia group and normal uric acid group(P>0.05).The blood glucose and blood lipid levels were significantly higher in hyperuricemia group than in normal uric acid group(P<0.05).The incidences of IMT thickening,plaque on both sides of carotid artery,carotid stenosis and hard plaque were significantly higher in hyperuricemia group than in normal uric acid group(P<0.05).The incidences of IMT thickening,bilateral plaque,hard plaque and carotid stenosis in hyperuricemia patients with hypertension or stoke were higher than those in hyperuricemia patients with diabetes or coronary heart disease(P<0.05).Conclusion For college retired workers,the incidences of IMT thickening,bilateral plaques and stenosis of the carotid artery in the hyperuricemia population are significantly higher than those with normal blood uric acid,and it is necessary to focus on the carotid plaque of hyperuricemia patients with stroke or hypertension,and make the corresponding prevention and treatment me
作者
夏蓉晖
聂颖
赵绵松
邱文风
孙亚慧
王伟
刘博
XIA Ronghui;NIE Ying;ZHAO Miansong;QIU Wenfeng;SUN Yahui;WANG Wei;LIU Bo(Department of Internal Medicine,Beijing Jiaotong University Community Health Center,Beijing 100044,China;Department of Rheumatology,Beijing Shijitan HospitalAffiliated to Capital Medical University)
出处
《山西医科大学学报》
CAS
2018年第12期1471-1475,共5页
Journal of Shanxi Medical University
基金
北京交通大学基本科研基金自由申报项目(016JB00040)
关键词
高校退休职工
血尿酸
颈动脉粥样硬化
相关性
colleges retired workers
blood uric acid
carotid atherosclerosis
correlation
