摘要
针对目前大环内酯类药物分离纯化过程存在的问题,以3种典型的大环内酯类抗生素(红霉素、阿奇霉素和克拉霉素)为例,采用界面聚合法并结合3种改性方法构建了结构与性能各异的聚酰胺活性分离层,探讨了有机溶剂纳滤(OSN)膜的表面形貌、化学组成、孔径及润湿性,评估了大环内酯类药物纯化过程中膜样品对药物溶质的分离性能,讨论了改性方法对纯化过程的影响.实验结果表明芳纶基OSN膜对4种溶剂中的阿奇霉素、红霉素和克拉霉素的截留率分别达到99.9%±0.0%(阿奇霉素/乙醇)、95.4%±2.8%(红霉素/甲醇)、97.0%±1.4%(红霉素/乙酸正丁酯)和99.8%±0.0%(克拉霉素/丙酮),因而具有良好的应用前景.
On the basis of the present problems in the separation and purification process of macrolides,three typical macrolide antibiotics(erythromycin,azithromycin and clarithromycin)were used as examples in this paper.Active polyamide separation layers with different structures and properties were constructed by adopting interfacial polymerization and three modification methods.The surface morphology,chemical composition,pore size and wettability of aramid-based organic solvent nanofiltration(OSN)membrane were investigated.The separation performance of macrolides in the purification processes were evaluated.And the influence of modification methods on the purification process were discussed.The experimental results showed that the rejection of azithromycin,erythromycin and clarithromycin in four solvents were 99.9%±0.0%(azithromycin/ethanol),95.4%±2.8%(erythromycin/methanol),97.0%±1.4%(erythromycin/butyl acetate)and 99.8%±0.0%(clarithromycin/acetone),respectively.Therefore,aramid-based OSN membranes have the good potential application in the separation and purification process of macrolides.
作者
徐孙杰
沈倩
罗立汉
许振良
于佳瑶
曹兰
崔玥晗
李慧
XU Sunjie;SHEN Qian;LUO Lihan;XU Zhenliang;YU Jiayao;CAO Lan;CUI Yuehan;LI Hui(State Key Laboratory of Chemical Engineering, Membrane Science and Engineering R&D Lab, Chemical Engineering Research Center, School of Chemical Engineering, East China University of Science and Technology, Shanghai 200237, China)
出处
《膜科学与技术》
CAS
CSCD
北大核心
2021年第3期111-117,134,共8页
Membrane Science and Technology
基金
国家自然科学基金项目(22078092,21978081,21808060)
教育部高校基本业务费项目(JKA012011001,JKA012011017)。
关键词
有机溶剂纳滤
芳纶
大环内酯抗生素
分离纯化
organic solvent nanofiltration
aramid
macrolide antibiotics
separation and purification
