摘要
急性肺损伤(ALI)和急性呼吸窘迫综合征(ARDS)的特点是肺泡上皮细胞、毛细血管内皮细胞屏障功能破坏以及炎性细胞募集,并导致肺泡及间质水肿、透明膜形成和肺部炎性浸润等,其机制尚未完全明确。目前的治疗方案以呼吸机支持治疗、液体管理、营养支持等综合性治疗为主,但预后仍较差。研究显示,不同来源的胞外囊泡微小RNA(miRNA)以不同方式参与调节上皮细胞、内皮细胞、吞噬细胞的功能,从而加重或改善ALI,并具有诊断、鉴别诊断及治疗价值。本文就相关ALI模型中不同来源的胞外囊泡miRNA在ALI中的调节机制、诊断与鉴别价值及干细胞胞外囊泡miRNA在治疗中的应用进行综述。
Acute lung injury(ALI)and acute respiratory distress syndrome(ARDS)are characterized by the destruction of the barrier function of alveolar epithelial cells and capillary endothelial cells and the recruitment of inflammatory cells,which leads to alveolar and interstitial edema,hyaline membrane formation and inflammatory infiltration of the lungs,etc.The mechanism is not completely defined.The current treatment plan focuses on comprehensive treatments such as ventilator support treatment,fluid management,and nutritional support,but the prognosis is still poor.Studies have shown that extracellular vesicle microRNA(miRNA)from different sources participate in regulating the function of epithelial cells,endothelial cells and phagocytes in different ways,thus aggravating or improving ALI,and have diagnostic,differential diagnosis and the therapeutic value.In this article,the mechanism,diagnostic and differerntial value of extracellular vesicle miRNA from different sources in ALI and the therapy of extracellular vesicle miRNA from stem cell in ALI are reviewed.
作者
任颖聪
陈淼
刘鑫鑫
冯帮海
Ren Yingcong;Chen Miao;Liu Xinxin;Feng Banghai(Department of Critical Care Medicine,Affiliated Hospital of Zunyi Medical University,Zunyi 563000,Guizhou,China)
出处
《中华危重病急救医学》
CAS
CSCD
北大核心
2021年第5期633-637,共5页
Chinese Critical Care Medicine
基金
国家自然科学基金 (81960024)。
