摘要
随着糖尿病患病率日趋增加,糖尿病性心肌病(diabetic cardiomyopathy,DCM)也越来越受到关注。糖尿病性心肌病的致病因素很多,氧化应激是DCM的重要风险因素,慢性高血糖通过产生大量活性氧(ROS)损伤抗氧化防御系统和增加氧化应激导致心肌病理异常。已有研究证实运动可以降低糖尿病活性氧簇生成、增强抗氧化应激能力,有利于心肌保护。该文就运动调节DCM模型鼠和患者氧化应激水平以及不同运动方式改善DCM的相关机制进行综述,为运动缓解糖尿病性心肌病的发病进程提供理论依据。
With the increasing prevalence of diabetes,diabetic cardiomyopathy(DCM)has also received more and more attention.There are many risk factors for DCM including oxidative stress.Chronic hyperglycemia can damage the antioxidant defense system by producing a large amount of reactive oxygen species(ROS)and increase oxidative stress,which leads to pathological abnormalities of the myocardium.It has been confirmed that exercise can reduce the formation of ROS in diabetes and enhance the ability of antioxidant stress,which is conducive to myocardial protection.In the review,we dicussed the role of exercise in regulating oxidative stress in diabetic cardiomyopathy,and summarized the current situation of intervention of different exercise modes on oxidative stress in DCM,so as to provide scientific basis for alleviating the pathogenesis of diabetic cardiomyopathy through exercise.
作者
马坤
谢金凤
刘金美
付翠元
贾绍辉
MA Kun;XIE Jin-Feng;LIU Jin-Mei;FU Cui-Yuan;JIA Shao-Hui(Graduate School of Wuhan Sports University,Wuhan 430079,China;Medical School of Hubei Minzu University,Enshi 445000,China;Hubei Key Laboratory of Sport Training and Monitoring,College of Health Science,Wuhan Sports University,Wuhan 430079,China)
出处
《生命科学》
CSCD
北大核心
2021年第4期490-501,共12页
Chinese Bulletin of Life Sciences
基金
湖北省自然科学基金项目(2018CFB729)
湖北省教育厅科学研究计划项目(B2019193)。
关键词
运动
糖尿病性心肌病
氧化应激
exercise
diabetic cardiomyopathy
oxidative stress
