摘要
目的观察右归丸联合二陈汤加减对多囊卵巢综合征(PCOS)的疗效及其对血清血管生成素样蛋白(Angptl)-2、Angptl-4和可溶性血管内皮生长因子受体-1(sFlt-1)的影响。方法采用随机数字表法将92例PCOS患者分为观察组和对照组,每组46例。对照组采用常规西药治疗,观察组在对照组基础上采用右归丸联合二陈汤加减治疗。比较2组疗效和不良反应,并比较2组治疗前后痤疮评分、宫颈黏液评分、卵巢体积、卵泡数量、阻力指数(RI)、搏动指数(PI)、平均血流速度(V m)和血清雌二醇、黄体生成素、促卵泡素、泌乳素、Angptl-2、Angptl-4、sFlt-1水平差异。结果观察组总有效率为95.65%,高于对照组的78.26%,差异有统计学意义(P<0.05)。观察组不良反应发生率为4.35%,低于对照组的19.57%,差异有统计学意义(P<0.05)。治疗后,2组痤疮评分、RI、PI、V m和雌二醇、黄体生成素、促卵泡素、泌乳素、Angptl-2、sFlt-1水平低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.01);治疗后,2组卵巢体积小于治疗前,卵泡数量少于治疗前,且观察组卵巢体积小于对照组,卵泡数量少于对照组,差异有统计学意义(P<0.01);治疗后,2组宫颈黏液评分和Angptl-4水平高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.01)。结论右归丸联合二陈汤加减治疗PCOS疗效显著,可明显改善患者症状,降低性激素水平,改善子宫血液循环,其机理可能与调节血清Angptl-2、Angptl-4和sFlt-1水平有关。
Objective To observe the efficacy of Yougui Pill combined with modified Erchen Decoction in treating patients with polycystic ovary syndrome(PCOS),and its impact on serum angiopoietin-like protein(Angptl)-2,Angptl-4 and soluble fms-like tyrosine kinase receptor(sFlt)-1.Methods A total of 92 PCOS patients were divided into observation group and control group according to the random numerical method,with 46 cases in each group.The control group was treated with conventional western medicine,and the observation group was treated with Yougui Pill combined with modified Erchen Decoction on the basis of the control group.The efficacy and incidence of adverse reactions were compared between the two groups and the acne score,cervical mucus score,ovarian volume,follicle number,estradiol,luteinizing hormone,follicle stimulating hormone,prolactin,resistance index(RI),pulsatility index(PI),mean blood flow velocity(V m),Angptl-2,Angptl-4 and sFlt-1 levels were compared in two groups before and after treatment.Results The total effective rate in observation group was 95.65%,which was significantly higher than 78.26%in control group(P<0.05).The incidence of adverse reactions in the observation group was 4.35%,which was significantly lower than 19.57%in the control group(P<0.05).After treatment,the acne score,RI,PI,V m,estradiol,luteinizing hormone,follicle stimulating hormone,prolactin,Angptl-2 and sFlt-1 levels of two groups were lower than treatment before,and were lower in the observation group than those in the control group(P<0.01).After treatment,the ovarian volume in the two groups was smaller,and the number of follicles was less than that before treatment(P<0.01).The ovarian volume was smaller and the number of follicles in the observation group was less than those in the control(P<0.01).After treatment,the cervical mucus score and the level of Angptl-4 in the two groups were higher than before treatment,and the observation group was significantly higher than the control group(P<0.01).Conclusion Yougui Pill combined wit
作者
徐海霞
朱春兰
张尊胜
夏亦冬
张瑜
XU Haixia;ZHU Chunlan;ZHANG Zunsheng;XIA Yidong;ZHANG Yu(Department of Gynecology,The Seventh People′s Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai,200137;Department of Gynecology,Shanghai Hospital of Traditional Chinese Medicine,Shanghai,200071)
出处
《实用临床医药杂志》
CAS
2021年第10期107-111,115,共6页
Journal of Clinical Medicine in Practice
基金
上海市浦东新区卫生健康委员会优势专病建设项目(PWZzb2017-04)
上海中医药大学附属第七人民医院“中医继承人”人才培养计划资助项目(JCR2017-02)。
