摘要
目的本研究探讨NLRP3基因多态性与汉族男性痛风患者之间的相关性。方法采用病例对照研究,参照痛风的诊断标准从新疆医科大学附属医院各门诊和住院部收集290例汉族男性原发性痛风患者,同时从体检中心收集302例汉族男性健康对照者,并且对两组NLRP3基因位点进行基因分型,建立单因素Logistic回归模型,分析痛风发病相关危险因素。结果NLRP3基因对照组3个SNP位点在该地区汉族人群满足Hardy-Weinberg平衡性检验(P>0.05),该地区人群中rs7525979位点痛风组基因型频率与对照组比较,差异有统计学意义(P<0.05)。结论痛风的发病与代谢综合征各组分密切相关,单因素Logistic回归模型进行分析显示,吸烟、高血糖、高尿酸能够增加痛风发病的风险(P<0.05)。单倍型分析发现CTT单倍型痛风组的频率高于对照组可能是痛风发生的危险因素(P<0.05)。
Objective This study explored the relationship between NLRP3 gene polymorphism and male gout patients of Han nationality.Methods Using a case-control study,according to the diagnostic criteria for gout,290 Han male patients with primary gout were collected from the outpatient and inpatient departments of the Affiliated Hospital of Xinjiang Medical University,and 302 Han male healthy controls were collected from the physical examination center.Group NLRP3 gene locus for genotyping,and establish a single factor Logistic regression model to analyze risk factors related to the onset of gout.Results The 3 SNP loci in the control group of NLRP3 gene satisfy the Hardy-Weinberg balance test(HWE)in the Han population in this area(P>0.05);the gout frequency of gout group at the rs7525979 locus is significantly higher than that in the control group(P<0.05).Conclusion The onset of gout is closely related to the components of the metabolic syndrome.Single factor Logistic regression model analysis shows that smoking,hyperglycemia,and hyperuric acid can increase the risk of gout(P<0.05).Haplotype analysis found that the frequency of CTT haplotype gout group was higher than that of control group,which may be a risk factor for gout(P<0.05).
作者
迪丽拜尔·阿吉木
王宇婷
叶飞
苗蕾
Dilibaier·Ajimu;Wang Yuting;Ye Fei(School of Public Health,Xinjiang Medical University,Xinjiang 830011,China)
出处
《医学研究杂志》
2021年第6期41-44,49,共5页
Journal of Medical Research
基金
国家自然科学基金资助项目(81460153)。
