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核仁素在原发性鼻咽癌中定位、定量表达及意义 被引量:1

Clinical positioning and quantitative expressions of nucleolin in primary nasopharynx cancer
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摘要 目的探讨核仁素在原发性鼻咽癌、炎症上皮组织中表达情况及临床意义。方法选择2018年~2020年接受诊治的原发性鼻咽癌患者90例,慢性鼻咽炎患者90例,均应用免疫组化SP法检测原发性鼻咽癌组织与炎症上皮组织核仁素的表达水平;评估核仁素表达定位、定量的差异,研究原发性鼻咽癌的各项临床指标与核仁素表达的相关性。结果原发性鼻咽癌病灶组织核仁素表达定量(7.8±0.7),与非肿瘤组织核仁素表达定量(3.8±0.2)相比,差异有统计学意义(t=52.12,P<0.05);与慢性鼻咽炎核仁素表达定量(5.6±0.3)相比,差异有统计学意义(t=27.41,P<0.05);原发性鼻咽癌90例细胞质表达核仁素81例(90.0%),细胞核表达核仁素72例(80.0%),原发性鼻咽癌旁正常组织细胞核表达核仁素18例(20.0%),细胞质表达核仁素36例(4.0%),差异有统计学意义(P<0.05)。原发性鼻咽癌核仁素在细胞核、细胞质中的阳性表达情况与TNM分期、颈部淋巴结转移密切相关,差异有统计学意义(P<0.05)。结论原发性鼻咽癌的核仁素表达水平显著增高,且出现核外迁移,可用于评估原发性鼻咽癌的预后情况。 Objective To discuss the clinical expression and significance of nucleolin in primary nasopharynx cancer and inflammatory epithelial tissues.Methods 90 primary nasopharynx cancer patients(2018~2020)and 90 chronic nasopharyngitis patients were selected.SP method was used to detect nucleolin expressions in primary nasopharynx cancer and inflammatory epithelial tissues.Clinical expressions,positioning and quantitation of nucleolin were evaluated.Correlation of clinical indicators with nucleolin expressions was probed.Results Quantitative expressions of nucleolin in primary nasopharynx cancer and inflammatory epithelial tissues were(7.8±0.7)and(3.8±0.2),with statistically significant difference(t=52.12,P<0.05);quantitative expressions of nucleolin in chronic nasopharyngitis were(5.6±0.3)(t=27.41,P<0.05);Among 50 primary nasopharynx cancer patients,there were 81 cytoplasmic expression cases(90.0%)and 72 nuclear expression cases(80.0%);in para-carcinoma tissues,there were 18 nuclear expression cases(20.0%)and 36 cytoplasmic expression cases(4.0%);the differences were statistically significant(P<0.05);positive cellular and cytoplasmic expressions of nucleolin in primary nasopharynx cancer were closely correlated with TNM staging and cervical lymph nodes(P<0.05).Conclusion The nucleolin expressions are remarkably increased with extranuclear migration,which can be used for prognosis evaluation of primary nasopharynx cancer.
作者 李红全 谭超华 周灿宦 李成之 蔡晓燕 LI Hong-quan;TAN Chao-hua;ZHOU Can-huan(Pathology Department,Taishan People’s Hospital,Taishan 529200,China)
出处 《中国处方药》 2021年第6期170-171,共2页 Journal of China Prescription Drug
基金 江门市科技计划项目(江科【2020】58号-2020YL1003)。
关键词 免疫组织化学 核仁素 原发性鼻咽癌 预后 Immunohistochemistry Nucleolin Primary nasopharynx cancer Prognosis
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