摘要
阿尔茨海默症(Alzheimer’s disease,AD)临床特征为进行性认知能力下降和记忆力减退,目前临床上仍未发现有效的药物和治疗途径从根本上防治AD的进展。槲皮素是一种黄酮类植物雌激素,可激动雌激素受体产生弱的雌激素活性,对神经系统具有保护作用。槲皮素具有较高的生物活性,且来源广泛,又无致畸,致癌和致死作用,逐渐受到了国内外学者广泛的关注。该文就槲皮素的生物活性、吸收、代谢,在AD中的神经保护作用以及作用机制作一综述,以期为AD相关治疗药物研究提供参考。
Alzheimer’s disease(AD)is characterized by progressive cognitive decline and memory loss,and its pathogenesis is complex.At present,no effective drugs and therapeutic approaches have been found clinically to fundamentally prevent and cure AD.Quercetin is a flavonoid phytoestrogen that simulates estrogen stimulation of estrogen receptors to produce weak estrogen activity and has a protective effect on the nervous system.Quercetin has high biological activity,wide source,no teratogenicity,no carcinogenesis,no lethal effect,so it has been widely concerned.In this review,the biological activity of quercetin,its neuroprotective effect on AD and its mechanism of action were reviewed,with a view to providing reference for the research of related drugs for AD.
作者
赵雨薇
甄艳杰
戴月英
沈丽霞
ZHAO Yu-wei;ZHEN Yan-jie;DAI Yue-ying;SHEN Li-xia(Department of Pharmacy,Hebei North University,Zhangjiakou,075000,China)
出处
《神经药理学报》
2020年第5期55-64,共10页
Acta Neuropharmacologica
基金
河北省自然科学基金项目(No.H2019405057)
河北省高等学校科学技术技术研究项目(No.ZD2020136)。
