摘要
目的探索生长分化因子15(growth differentiation factor 15,GDF15)对碎死(sudden death,SD)患者的预警预测价值。方法选取2018年1月至12月于解放军总医院第一临床中心急诊科就诊的SD患者49名纳入病例组,随机(随机数字法)选取于解放军总医院体检中心就诊的健康查体人员46名纳人对照组,进行一般情况、心肌标记物比较及病例组基本资料分析,从而评估SD时各心肌标记物的预警价值。结果年龄在40-49岁之间的病例在SD病例中最高,达26.54%。60岁以下的SD占比达59.19%,且男女比为3.83:1。病例组与对照组对比发现,CKMB[(41.35±98.38)vs(3.13±2.17),P=0.009]、肌酸激酶[(2652.82±6845.66)vs.(102.73±47.93),P=0.012]、GDF15[(549.80±809.79)vs.(115.70±167.42),P=0.001]。同时对病例组中各个心肌标志物比较发现,GDF15对应的AUC值为0.816,对于SD的诊断价值最高。且CK-MB、CK及GDF15与年龄未表现出相关性:结论GDF15作为生物学标记物,在SD方面具有很好地预警作用。
Objective To explore the early warning and prediction value of GDF15 for sudden death patients.Methods From January to December 2018,49 patients with sudden death who were treated in the Emergency Department of the First Clinical Center of PLA General Hospital were included in the case group,and 46 healthy physical examiners in the Physical Examination Center of the Hospital were randomly selected as the control group.The general situation,comparison of myocardial markers and analysis of the basic data of the case group were carried out,so as to evaluate the early warning value of each myocardial marker in sudden death.Results Patients aged 40-49 years old accounted the highest proportion among sudden death cases,reaching 26.54%.Sudden death under 60 years old accounted for 59.19%,and the ratio of male to female was 3.83:1.There were significant differences between the case group and the control group in CK-MB[(41.35±98.38)vs.(3.13±2.17),P=0.009],CK[(2652.82±6845.66)vs.(102.73±47.93),P=0.012],and GDF15[(549.80±809.79)vs.(115.70±167.42),P=0.001].At the same time,the AUC value of GDF15 was 0.816,which has the highest diagnostic value for sudden death.And CK-MB,CK and GDF15 had no correlation with age.Conclusions GDF15,as a biological marker,has a good early warning function in sudden death.
作者
昌上清
盛云婧
韩国鑫
李朔朔
朱海燕
Chang Shangqing;Sheng Yunjing;Han Guoxin;Li Shuoshuo;Zhu Haiyan(Department of Emergency Medicine,Hainan Hospital of PLA General Hospital,Sanya 572013,China;Department of Emergency Medicine,Characteristic Medical Center of PLA Strategic Support Force,Beijing 100024,China;Department of Ultrasound Medicine,The First Medical Center of PLA General Hospital,Beijing 100853,China;Department of Emergency Medicine,The First Medical Center of PLA General Hospital,Beijing 100853,China)
出处
《中华急诊医学杂志》
CAS
CSCD
北大核心
2021年第6期689-693,共5页
Chinese Journal of Emergency Medicine
基金
科技部国家重点研发计划(2019YFC0119600)
联勤保障部队战勤局重大项目(ALB19J003)
海南省重大科技计划(ZDKJ202004)
解放军总医院转化医学项目(2018TM-06)
军事医学研究专项(2018FC-WJFWZX-1-l9)。
关键词
猝死
生长分化因子15
心肌标记物
冠心病
急性心肌梗死
肌钙蛋白T
肌酸激酶
肌酸激酶同工酶
Sudden death
Growth differentiation factor 15
Cardiac markers
Coronary heart disease
Acute myocardial infarction
Troponin t
Creatine Kinase
Creatine Kinase isoenzyme MB
