摘要
目的对格列本脲与门冬胰岛素在妊娠期糖尿病(GDM)患者中的治疗效果进行分析。方法将2019年1月-2020年1月沈阳市中医药学校附属医院收治GDM患者80例作该次研究对象,随机数字表的方式分组(观察组40例,对照组40例),对照组行门冬胰岛素疗法,观察组基于对照组基础之上行格列本脲治疗,对比最终结果。结果治疗前,观察组患者的空腹血糖(FPG)、糖化血红蛋白(HbA1c)、餐后2 h血糖(2 hPG)均与对照组差异无统计学意义(P﹥0.05);经治疗,观察组患者FPG、HbA1c、2 hPG数据比对照组优,差异有统计学意义(P<0.05)。观察组患者的并发症发生率为2.50%,而对照组患者的并发症发生率为15.00%,差异有统计学意义(P<0.05)。治疗前,两组患者实验室指标差异无统计学意义(P﹥0.05),经治疗,观察组患者实验室指标(总胆红素、总胆固醇、尿微量蛋白及尿酸)数据比对照组优,差异有统计学意义(P<0.05)。结论对GDM患者使用格列本脲与门冬胰岛素进行治疗,能够很好缓解患者临床基本症状,降低其并发症发生概率,使治疗效果更佳。
Objective To analyze the therapeutic effects of glibenclamide and insulin aspart in patients with gestational diabetes(GDM).Methods From January 2019 to January 2020,80 cases of GDM patients admitted to the affiliated hospital of Shenyang School of Traditional Chinese Medicine were selected as the subjects of this study,and grouped by random number table(observation group 40 cases,control group 40 cases);the control group was treated with insulin aspart,and the observation group was treated with glibenclamide on the basis of the control group,and the final results were compared.Results Before treatment,the fasting blood glucose(FPG),glycosylated hemoglobin(HbA1c),and postprandial blood glucose(2 hPG)of the observation group were not statistically significantly different from those of the control group(P>0.05);after treatment,the observation group had FPG,the data of HbA1c and 2 hPG were better than those of the control group,and the difference was statistically significant(P<0.05).The complication rate in the observation group was 2.50%,while the complication rate in the control group was 15.00%,and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in laboratory indicators between the two groups of patients(P>0.05).After treatment,the laboratory indicators(total bilirubin,total cholesterol,urine microprotein and uric acid)of the observation group were better than those of the control group,and the difference was statistically significant(P<0.05).Conclusion The use of glibenclamide and insulin aspart for the treatment of GDM patients can well alleviate the basic clinical symptoms of the patients,reduce the probability of complications,and make the treatment effect better.
作者
孙瑾
SUN Jin(Shenyang Chinese Medicine School Training Center,Shenyang,Liaoning,110300 China)
出处
《糖尿病新世界》
2021年第8期81-84,共4页
Diabetes New World Magazine
