摘要
目的观察阿奇霉素序贯治疗对于支原体肺炎患儿肺功能、血清炎性反应标志物的影响。方法选取2018年1月~2020年1月收治的86例支原体肺炎患儿纳入研究,将入选患儿按随机数字表划分为常规组与序贯组,常规组采用阿奇霉素常规治疗,序贯组采用阿奇霉素序贯治疗,治疗1疗程后,对比两组患儿临床疗效,统计两组患儿主要症状消失时间;观察治疗前后两组患儿肺功能、血清炎性反应标志物表达水平的变化情况,统计治疗期间不良反应发生率。结果序贯组总有效率为95.35%,常规组为93.02%,两组总有效率与临床疗效均无统计学差异(P>0.05)。两组患儿主要症状消失时间均无统计学差异(P>0.05)。两组患儿各项肺功能指标均较本组治疗前改善(P<0.05),两组治疗前后均无统计学差异(P>0.05)。治疗后两组患儿血清CRP、IL-6、TNF-α、TNF-β均较治疗前改善(P<0.05),两组CRP、IL-6、TNF-α均无统计学差异(P>0.05),序贯组患儿TNF-β高于常规组(P<0.05)。序贯组不良反应发生率为4.65%,常规组为27.91%,序贯组低于常规组(P<0.05)。结论阿奇霉素序贯治疗可达到常规治疗的临床疗效水平,能够有效改善患儿肺功能、抑制炎性反应程度且均可达到常规治疗水平,但序贯治疗可更好的增强患儿免疫功能且治疗安全性更高。
Objective To observe the effect of azithromycin sequential therapy on lung function and serum inflammatory response markers in children with mycoplasma pneumonia. Methods Our hospital from January 2018 to January 2020 were among the 86 cases of mycoplasma pneumonia in children, the children will be selected according to random number table is divided into normal group and sequential group and routine group with azithromycin routine therapy, sequential group with azithromycin sequential therapy, after 1 course of treatment, compared two groups of clinical curative effect, statistics of two groups of children with main symptoms disappear time;The changes of lung function and serum inflammatory response markers were observed before and after treatment, and the incidence of adverse reactions during treatment was counted. Results The total effective rate was 95.35% in the sequential group and 93.02% in the conventional group. There was no statistical difference between the total effective rate and clinical efficacy between the two groups(P>0.05). There was no significant difference in the disappearance time of major symptoms between the two groups(P>0.05). All lung function indicators of the two groups were improved compared with the control group before treatment(P<0.05), and there was no statistical difference between the two groups before and after treatment(P>0.05). After treatment, the serum CRP, IL-6, TNF-α and TNF-β of the two groups were all improved compared with that before treatment(P<0.05). There were no statistically significant differences in CRP, IL-6 and TNF-α between the two groups(P>0.05), and TNF-β of the sequential group was higher than that of the conventional group(P<0.05). The incidence of adverse reactions was 4.65% in the sequential group and 27.91% in the conventional group, which was lower than that in the conventional group(P<0.05). Conclusions Azithromycin sequential therapy can achieve the clinical efficacy level of conventional treatment, can effectively improve the pulmonary functio
作者
蒋士才
王曦聆
JIANG Shicai;WANG Xiling(Zhengzhou Children's Hospital,Henan Provincial Children's Hospital 450053)
出处
《航空航天医学杂志》
2021年第5期526-529,共4页
Journal of Aerospace medicine
关键词
肺炎支原体感染
支原体肺炎
儿童
阿奇霉素
序贯治疗
肺功能
血清炎性反应标志物
Mycoplasma pneumoniae infection
Mycoplasma pneumonia
Children
Azithromycin
Sequential therapy
Lung function
Serum markers of inflammatory response
