摘要
目的:探讨痰热清注射液联合阿奇霉素治疗小儿支原体肺炎的临床疗效及对机体炎症因子的影响。方法:选择儿科治疗的确诊为小儿支原体肺炎的72例患儿作为观察对象,采用随机数字表法将其分为观察组和对照组各36例,均给予院内常规诊疗及护理措施,对照组在以上基础上给予阿奇霉素静脉滴注治疗,观察组在对照组基础上联合应用痰热清注射液静脉滴注治疗,治疗10~14 d,对比两组患儿临床疗效及机体炎症因子水平的变化。结果:观察组总有效率97.22%显著高于对照组的83.33%,两组比较差异有统计学意义(P<0.05);观察组患儿咳嗽、发热、肺部阴影及肺部罗音消失时间均明显短于对照组,两组比较差异有统计学意义(P<0.05);两组治疗3 d时TNF-α、IL-6及CRP指标均有所下降,与治疗前比较差异均有统计学意义(P<0.05),但观察组改善更明显,组间比较有显著性差异(P<0.05);治疗6 d时各炎性因子指标下降更为显著,与治疗前比较差异均有统计学意义(P<0.05),且观察组改善更为明显,组间比较有显著性差异(P<0.05)。结论:痰热清注射液能在一定程度上明显降低患儿肺炎血清中的各类炎性因子的水平,且临床与阿奇霉素联用过程中未见明显不良反应,值得临床推广应用。
Objective： To investigate the clinical effect of Tanreqing Injection combined with azithromycin in the treatment of mycoplasmal pneumonia in children and its influence on inflammatory factors. Methods： Seventy-two children with mycoplasmal pneumonia were selected as pediatric patients. All were divided into observation group and control group（ 36 cases in each group） by random number table method. All the patients were given routine nursing and nursing measures. On the basis of azithromycin intravenous infusion,the observation group was given Tanreqing Injection intravenous infusion treatment. The clinical efficacy and changes in the level of inflammatory factors were compared between the two groups. Results： The total effective rate of the observation group was 97. 22% and significantly higher than 83. 33%of the control group and the difference between the two groups was statistically significant（ P〈0. 05）. The cough,fever,lung shadow and lung rales disappeared（ P〈0. 05）. The levels of TNF-α,IL-6 and CRP in the two groups were significantly lower than those in the control group and the difference was statistically significant（ P〈0. 05）. The difference of the inflammatory factors were more significant at 6 days after treatment（ P〈0. 05） and the improvement was more obvious in the observation group. There was significant difference between the two groups（ P〈0. 05）. Conclusion： Tanreqing Injection can significantly reduce the levels of various inflammatory factors in children with pneumonia and it is not suitable for clinical application with azithromycin. It is worthy of clinical application.
出处
《中华中医药学刊》
CAS
北大核心
2017年第9期2418-2420,共3页
Chinese Archives of Traditional Chinese Medicine
基金
海南省自然科学基金项目(20168293)
关键词
小儿支原体肺炎
痰热清注射液
阿奇霉素
炎症因子
pediatric mycoplasma pneumonia
Tanreqing Injection
azithromycin
inflammatory factors
