摘要
目的:探讨血清β-绒毛膜促性腺激素(β-HCG)、降钙素原(PCT)、C反应蛋白(CRP)及分泌物B族链球菌(GBS)联合检查在预测胎膜早破孕妇并发绒毛膜羊膜炎及新生儿感染的临床价值。方法:选取2019年09月至2020年09月于我院收治的300例孕妇作为研究对象,其中100例足月胎膜早破孕妇(足月胎膜早破组),100例未足月胎膜早破孕妇(未足月胎膜早破组),100例无胎膜早破经剖宫产终止妊娠孕妇(对照组)。检测孕妇血清β-HCG、PCT、CRP水平和GBS阳性率,并检测新生儿脐血PCT、CRP及脐动脉血气分析。结果:未足月胎膜早破组血清β-HCG、PCT、CRP水平和GBS阳性率高于足月胎膜早破组和对照组(P<0.05);绒毛膜羊膜炎组血清β-HCG、PCT、CRP水平和GBS阳性率高于非绒毛膜羊膜炎组(P<0.05);ROC曲线分析显示,血清β-HCG、PCT、CRP水平串联检测胎膜早破孕妇并发绒毛膜羊膜炎的敏感度及AUC高于单独检测(P<0.05)。败血症组脐血PCT、CRP水平高于新生儿肺炎组、非感染组及对照组(P<0.05)。结论:胎膜早破孕妇血清β-HCG、PCT、CRP水平和GBS阳性率升高,四者联合预测绒毛膜羊膜炎价值较高,脐带血中PCT、CRP水平有利于早期诊断新生儿感染。
Objective:To investigate the clinical value of combined examination of serumβ-chorionic gonadotropin(β-HCG),procalcitonin(PCT)and C-reactive protein(CRP)and secretion group B streptococcus(GBS)in predicting chorioamnionitis and neonatal infection in pregnant women with premature rupture of membranes(PROM).Methods:From September 2019 to September 2020,300 pregnant women were selected,including 100 cases with PROM of term(tPROM group),100 cases with preterm PROM(PPROM),and 100 pregnant women without PROM undergoing termination of pregnancy by cesarean section(control group).Maternal serumβ-HCG,PCT and CRP levels and GBS positive rate,neonatal cord blood PCT and CRP were detected.Results:Serumβ-HCG,PCT and CRP levels and GBS positive rate in the PPROM group were higher than those in the tPROM group and control group(P<0.05).Besides,serumβ-HCG,PCT and CRP levels and GBS positive rate in the chorioamnionitis group were higher than those in the non-chorioamnionitis group(P<0.05).ROC curve analysis showed that the sensitivity and AUC of serumβ-HCG,PCT and CRP levels in tandem detection of pregnant women with premature rupture of membranes complicated with chorionic amnitis were higher than those of single detection(P<0.05).Cord blood PCT and CRP levels in sepsis group were higher than those in the neonatal pneumonia group,non-infection group and control group(P<0.05).Conclusion:Pregnant women with PROM have elevated serumβ-HCG,PCT and CRP levels and GBS positive rate.Combination of the four has higher value in predicting chorioamnionitis.Cord blood PCT and CRP levels can help early diagnosis of neonatal infection.
作者
高艳杰
龚春桃
汪海霞
却颖睿
蔡红莲
GAO Yanjie;GONG Chuntao;WANG Haixia(Aikang Hospital of Huangshi, Hubei Huangshi 435000, China)
出处
《河北医学》
CAS
2021年第6期930-934,共5页
Hebei Medicine
基金
湖北省卫生健康委员会联合基金项目,(编号:WJ2019H470)。
