摘要
目的探讨未足月胎膜早破孕妇血清中Gal-1、Gal-3水平对亚临床绒毛膜羊膜炎的预测价值。方法选取2019年4月至2020年3月于徐州医科大学附属医院住院分娩的未足月胎膜早破孕妇(妊娠28~33周+6)40例,选取同期与之胎龄匹配的无产科并发症的孕妇40例作为对照。测定母体血清中Gal-1、Gal-3的表达水平,未足月胎膜早破孕妇分娩后取胎膜组织进行病理学检查。结果未足月胎膜早破孕妇血清中Gal-1[4.89(4.34~5.97)ng/mL]、Gal-3[43.72(38.99~47.02)ng/mL]水平明显高于对照组(P<0.05),差异具有统计学意义。未足月胎膜早破合并有亚临床绒毛膜羊膜炎孕妇血清中Gal-1[5.91(5.09~6.22)ng/mL]、Gal-3[47.01(45.54~48.76)ng/mL]水平明显高于未足月胎膜早破孕妇未合并亚临床绒毛膜羊膜炎组(P<0.05),差异具有统计学意义。ROC曲线分析结果,Gal-1、Gal-3诊断未足月胎膜早破合并亚临床绒毛膜羊膜炎的灵敏度分别为77.8%、88.3%;特异性分别为86.4%,95.5%。结论未足月胎膜早破合并亚临床绒毛膜羊膜炎孕妇血清中Gal-1、Gal-3水平显著升高,Gal-1、Gal-3可能既是未足月胎膜早破病理生理的启动因子,也是预测PPROM合并亚临床绒毛膜羊膜炎的标志物。
Objective To explore the predictive value of serum Gal-1 and Gal-3 levels in preterm premature rupture of membranes in subclinical chorioamnionitis.Methods We selected 40 preterm premature rupture of membranes(28-33+6 weeks)pregnant women(28-33+6 weeks)who were hospitalized in the Affiliated Hospital of Xuzhou Medical University from April,2019 to March,2020,and also selected forty pregnant women with the term matched term without obstetric complications during the same period who gave birth served as controls.The levels of Gal-1 and Gal-3 in maternal serum of all subjects were determined.The fetal membrane tissues were taken for pathological examination after delivery of pregnant women with preterm premature rupture of membranes.Results The levels of Gal-1[4.89(4.34-5.97)ng/mL]and Gal-3[43.72(38.99-47.02)ng/mL]in the serum of pregnant women with preterm premature rupture of membranes were significantly higher than those of the control group(P<0.05).Serum levels of Gal-1 and Gal-3 in pregnant women with preterm premature rupture of membranes and subclinical chorioamnionitis were significantly higher than those in the preterm premature rupture of membranes without subclinical chorioamnionitis(P<0.05).ROC curve analysis results showed that the sensitivity of Gal-1[5.91(5.09-6.22)ng/mL]and Gal-3[47.01(45.54-48.76)ng/mL]in diagnosing preterm premature rupture of membranes with subclinical chorioamnionitis were 77.8%and 88.3%and the specificities were 86.4%and 95.5%,respectively.Conclusion The levels of Gal-1 and Gal-3 in the serum of pregnant women with preterm premature rupture of membranes and subclinical chorioamnionitis are significantly increased.Gal-1 and Gal-3 may be both served as the pathophysiological initiating factors of preterm premature rupture of membranes,which could be used as a predictor of PPROM combined with subclinical chorioamnionitis.
作者
赵童童
孙礼强
邵丹卉
韩秋峪
ZHAO Tongtong;SUN Liqiang;SHAO Danhui;HAN Qiuyu(Graduate School, Xuzhou Medical University, Xuzhou 221004, China;Department of Obstetrics and Gynecology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, China)
出处
《标记免疫分析与临床》
CAS
2021年第2期235-239,共5页
Labeled Immunoassays and Clinical Medicine
基金
徐州市推动科技创新项目(编号:KC20121)。
