摘要
目的研究血清癌胚抗原(CEA)、人附睾蛋白4(HE4)、糖类抗原(CA)125、CA199单独和4项联合检测在卵巢癌中的诊断价值。方法选取2018年8月至2020年4月我院妇科卵巢瘤患者74例(卵巢癌组)、卵巢良性疾病患者39例(卵巢良性疾病组),健康体检女性119名(健康对照组),基于全自动电化学发光免疫分析仪分别对3组血清CEA、HE4、CA125、CA199的含量进行测定并对比,比较单独及联合检测上述血清指标对卵巢癌的诊断特异度、灵敏度、准确度;绘制受试者工作特征曲线(ROC曲线)评价上述4项肿瘤标志物单独和联合检测在卵巢癌诊断中的意义。结果卵巢癌组中血清CEA、HE4、CA125、CA199水平明显高于卵巢良性疾病组和健康对照组,差异具有统计学意义(P<0.05);联合检测的灵敏度、特异度和准确度高于单独检测;血清CEA、HE4、CA125、CA199和4项联合检测的曲线下面积分别为0.826、0.940、0.883、0.714、0.960,4项联合检测对卵巢癌诊断性能最好。结论联合检测血清CEA、HE4、CA125、CA199有助于提高卵巢癌的诊断性能。
Objective To investigate the diagnostic value of serum carcinoembryonic antigen(CEA),human epi-didymal protein 4(HE4),carbohydrate antigen(CA)125,CA199 alone and four combined tests in ovarian cancer.Methods From August 2018 to April 2020,74 patients with gynecological ovarioma(ovarian cancer group),39 patients with benign ovarian disease(ovarian benign disease group)and 119 healthy women(healthy control group)were selected.Serum CEA,HE4,CA125 and CA199 in the three groups were measured by automatic electrochemilum-inescence immunoanalyzer.The levels of serum CEA,HE4,CA125 and CA199 in the three groups were compared,and the diagnostic specificity,sensitivity and accuracy of the above serum indicators were compared separately and jointly for ovarian cancer.Receiver operating characteristic(ROC)curve was drawn to evaluate the significance of single and combined detection of the four tumor markers in the diagnosis of ovarian cancer.Results Serum CEA,HE4,CA125 and CA199 levels in ovarian cancer group were significantly higher than those in benign ovarian disease group and healthy control group,the difference was statistically significant(P<0.05).The sensitivity,specificity and accuracy of combined detection were higher than those of single detection.ROC analysis showed that the area under the curve of serum CEA,HE4,CA125,CA199 and the four combined tests were 0.826,0.940,0.883,0.714 and 0.960.The four combined tests had the best diagnostic performance for ovarian cancer.Conclusion Combined detection of serum CEA,HE4,CA125 and CA199 is helpful to improve the diagnostic performance of ovarian cancer.
作者
王建伟
谢海花
孙嘉峰
赖希希
Wang Jianwei;Xie Haihua;Sun Jiafeng;Lai Xixi(Clinical Laboratory,Fujian Provincial Hospital South Branch,Fuzhou 350008,China)
出处
《实用医技杂志》
2021年第6期723-725,F0003,共4页
Journal of Practical Medical Techniques
基金
福建省卫生健康中青年骨干人才培养项目(2019-ZQN-32)。
关键词
癌胚抗原
抗原
肿瘤相关
卵巢肿瘤
Carcinoembryonic antigen
Antigens,tumor-associated
Ovarian neoplasms
