摘要
目的探讨糖类抗原125（CA125）联合糖类抗原199（CA199）检测在妇科肿瘤诊断中的应用效果。方法选取2011年10月至2014年10月间收治的111例良性肿瘤妇科患者为良性肿瘤组,111例恶性肿瘤妇科患者为恶性肿瘤组,同时选取111例正常体检妇女为对照组,均行CA125、CA199检测,分析其在妇科肿瘤诊断中的诊断价值。结果良性肿瘤组患者CA125、CA199水平均明显高于对照组,差异有统计学意义（P〈0.05）。恶性肿瘤组患者CA125、CA199水平均明显高于对照组和良性肿瘤组,差异有统计学意义（P〈0.05）。CA125在〈35 U/mol、35-70 U/mol时,恶性肿瘤组患者CA125检出率均明显低于良性肿瘤组,差异有统计学意义（P〈0.05）。CA125在71-140 U/mol、141-280 U/mol、〉280 U/mol时,恶性肿瘤组CA125检出率均明显高于良性肿瘤组,差异有统计学意义（P〈0.05）。无论是CA125检测还是CA125＋CA199联合检测,CA125〉140 U/mol的敏感性均明显高于CA125≤140 U/mol,CA125〉140 U/mol的特异性均明显低于CA125≤140 U/mol,差异有统计学意义（P〈0.05）。CA125＋CA199联合检测的敏感性高于单独CA125检测,特异性低于CA125检测,差异有统计学意义（P〈0.05）。良性肿瘤组的CA125、CA125＋CA199检测的ROC曲线下面积分别为0.841和0.879;恶性肿瘤组的CA125、CA125＋CA199检测的ROC曲线下面积分别为0.901和0.967。结论 CA125联合CA199检测可提高CA125诊断的敏感性,具有较高的诊断价值。
Objective To investigate the application efficacy of carbohydrate antigen 125（ CA125） combined with carbohydrate antigen 199（ CA199） detection in the diagnosis of gynecological tumors. Methods From October 2014 to October 2011 in Maternal and Child Health Station of Yunhe Distract,111 benign tumor patients were selected as benign tumor group; 111 malignant tumor patients were selected as malignant tumor group; 111 normal physical examination women were selected as control group.CA125,CA199 expression levels in all patients were detected. Diagnostic value of CA125 different expression levels of gynecological tumor was analyzed. Results CA199 and CA125 expression level in benign tumor group were significantly higher than that of the control group（ P〈0. 05）. CA199 and CA125 in malignant tumor group were significantly higher than that of control group and benign tumor group（ P〈0. 05）.While CA125 in 0 - 35 U / mol and 35 - 70 U / mol,CA125 positive rate in malignant tumor group were lower than that of benign tumor group（ P〈0. 05）. While CA125 in 70 - 140 U / mol,140 - 280 U / mol, 280 U / mol,CA125 positive rate in malignant tumor group were higher than that of benign tumor group（ P〈0. 05）. Whether CA125 detection or CA125 ＋ CA199 combined detection,sensitivity of CA125 140 U / mol were significantly higher than CA125 0 - 140 U / mol（ P〈0. 05）. Specificity of CA125 140 U / mol were significantly lower than CA125 0 - 140 U / mol（ P〈0. 05）. Sensitivity of CA125 ＋CA199 combined detection was higher than CA125 detection（ P〈0. 05）. Specificity of CA125 ＋ CA199 combined detection was lower than CA125 detection（ P〈0. 05）. About receiver operating characteristic curve（ ROC）,in benign tumor group,area under curve of CA125,CA125 ＋ CA199 were 0. 841 and0. 879. In malignant tumor group,area under curve of CA125,CA125 ＋ CA199 were 0. 901 and 0. 967.Conclusion CA125 combined with CA199 can improve diagnostic sensitivity under low level CA125,which has higher diag
出处
《中国肿瘤临床与康复》
2016年第3期278-280,共3页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
妇科肿瘤
糖类抗原125
糖类抗原199
Gynecological neoplasms
Carbohydrate antigen 125
Carbohydrate antigen 199
