摘要
神经突方向离散度和密度成像(neurite orientation dispersion and density imaging,NODDI)是一种新型的磁共振扩散成像技术,可用于量化神经树突和轴突微观结构的复杂性,从而获取神经纤维的形态学信息。与目前广泛应用于临床的扩散张量成像(diffusion tensor imaging,DTI)相比,此类神经突指标对脑组织微观结构的评估更具有特异性和敏感性。阿尔茨海默症(Alzheimer’s disease,AD)是以进行性认知功能障碍和记忆力减退为特征的中枢神经系统退行性疾病,通过NODDI技术可以评估AD患者神经系统微观结构的复杂性。现就NODDI技术的基本原理和在AD中的研究进展进行综述。
Neurite direction dispersion and density imaging(NODDI)is a relatively practical diffusion magnetic resonance imaging technique that can be used to quantify the microstructure of nerve dendrites and axons,so as to obtain morphological information of nerve fibers.Compared with diffusion tensor imaging(DTI),which is widely used in clinical practice,these neurite indicators are more specific for the assessment of the microstructure of brain tissue.Alzheimer’s disease(AD)is a degenerative disease of the central nervous system characterized by progressive cognitive dysfunction and memory loss.Therefore,NODDI technology can be used to estimate the microstructure of the nervous system of AD patients.The basic principles of NODDI technology and the research progress in AD are reviewed.
作者
韦志豪
王红
WEI Zhihao;WANG Hong(Imaging Center of the Second Affiliated Hospital of Xinjiang Medical University,Urumqi 830063,China)
出处
《磁共振成像》
CAS
CSCD
北大核心
2021年第4期103-105,共3页
Chinese Journal of Magnetic Resonance Imaging
基金
新疆维吾尔自治区自然科学基金(编号:2019D01C227,2020D01C191)。
