摘要
目的观察黄蒲通窍胶囊治疗血管性痴呆(VaD)患者的临床疗效及安全性。方法将符合纳入病例标准的90例VaD患者随机分成3组,即西药多奈哌齐治疗组(A组),中医辨证后运用黄蒲通窍胶囊组(B组)和中医辨证后使用黄蒲通窍胶囊合用多奈哌齐组(C组)。疗程为60d。观察3组治疗后中医证候积分;神经心理学量表检查包括:简明精神状态检查量表(MMSE)、日常生活能力量表(ADL)、阿尔茨海默病评定量表-认知分量表(ADAS-Cog)。测定血液流变学及血清同型半胱氨酸(Hcy)。结果黄蒲通窍胶囊可以显著改善中医证候积分、ADL、MMSE、ADAS-cog积分,降低血Hcy且无明显不良反应。结论黄蒲通窍胶囊可以改善VaD患者的临床症状,是治疗血管性痴呆的安全有效药物。
Objective To observe the effeet of Huangputongqiao capsule in treatment of patients with vascular demenna（Vat））. Methods Ninety patients with vascular dementia were randomly di,,ided into three groups：Donepenil group （A group） treated with donepenil, Huangputongqiao capsule group （B group） treated with Huangputongqiao capsule,donepenil with huangputongqiao capsule group （C group） treated with donepenil and huangputongqiao capsule. The scores of TCM symptom, activity of daily living（ADL） scale,mini- mental state examination（MMSE）smart scale and the cognitive part of Alzheimer＇ s disease assessment scale（ADAS- cog） were calculated. The level of plasma homocysteine was tested Results The scores of TCM symptom,ADl.,MMSE and ADAS- cog were improved significantly in huangputongqiao capsule group. The level of plasma homocysteine was reduced in huangputongqiao capsule group,and there were no adverse effects. Conclusion Huangputongqiao cappsule could improve clinical symptoms in patients with vascular dementia, bluangputongqiao capsule was effective and safe for the treatment of vascular dementia.
出处
《中西医结合心脑血管病杂志》
2010年第1期41-43,共3页
Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
