摘要
目的:系统评价甘草泻心汤加味治疗放化疗后口腔溃疡的疗效。方法:全面检索国家知识基础设施数据库(CNKI)、PubMed等8个中英文数据库,收集甘草泻心汤加味治疗放化疗后口腔溃疡的随机对照试验学术论文,从建库至2020年9月为各数据库的检索时限,选取2位评价员筛查挑选文献、数据提取、评价偏倚风险后,应用RevMan 5.3对研究数据进行Meta分析。结果:初步检索到476篇文献,剔除重复及不符合纳入标准的文献后,最终纳入8个RCT,包括553例患者,观察组279例,对照组274例。甘草泻心汤加味治疗放化疗后口腔溃疡的总有效率(RR 1.29,95%CI为1.19~1.40,P<0.00001)、愈合时间(MD-3.16,95%CI为-4.65~-1.67,P<0.0001)、第5天疼痛缓解率(RR 1.72,95%CI为1.32~2.24,P<0.0001)、第7天疼痛缓解率(RR 1.41,95%CI为1.20~1.66,P<0.0001)等结局,与对照组比较,差异有统计学意义;亚组分析结果显示:与生理盐水组比较,在治疗有效率上,甘草泻心汤更高(RR 1.29,95%CI为1.16~1.43,P<0.00001)。结论:根据现有的文献资料,甘草泻心汤是治疗放、化疗后口腔溃疡的一个有效方剂。但限于纳入的研究的质量、数量,本研究结果的证实要求未来更高质量、更大样本的研究。
Objective:To systematically evaluate the effects of modifed Gancao Xiexin Decoction on oral ulcer after radiotherapy and chemotherapy.Methods:A comprehensive search of 8 Chinese and English databases such as the National Knowledge Infrastructure Database(CNKI)and PubMed,and the collection of randomized controlled trials academic papers on the treatment of oral ulcers after radiotherapy and chemotherapy with Gancao Xiexin Decoction,from the establishment of the database to September 2020 were retrieved.476 papers were initially retrieved.After excluding duplicates and documents that did not meet the inclusion criteria,8 RCTs were finally included,including 553 patients,279 cases in the test group,and 274 cases in the control group.2 reviewers were selected for screening and selection.After literature selection,data extraction,and evaluation of the risk of bias,RevMan 5.3 was used to conduct a meta-analysis of the research data.Results:The total effective rate of modifed Gancao Xiexin Decoction in the treatment of radiation and chemotherapy in patients with oral ulcers(RR 1.29,95%CI 1.19 to 1.40,P<0.00001);Healing time(MD-3.16,95%CI-4.65 to-1.67,P<0.0001),the pain relief rate on the 5 th day(RR 1.72,95%CI 1.32 to 2.24,P<0.0001);the pain relief rate on the 7 th day(RR 1.41,95%CI 1.20 to 1.66,P<0.0001),there was significant difference between the 2 groups;Subgroup analysis indicates:Compared with normal saline group,Ganxiexin Decoction was more effective in treating oral ulcers after radiotherapy and chemotherapy(R 1.29,95%CI 1.16 to 1.43,P<0.0001).Conclusion:According to the existing literature,Gancao Xiexin Decoction is an effective prescription for the treatment of oral ulcers after radiotherapy and chemotherapy.But limited to the quality and quantity of the included studies,the verification of the results of this study requires higher quality and larger samples in future studies.
作者
贺忠宁
王宝泉
张培彤
HE Zhongning;WANG Baoquan;ZHANG Peitong(Beijing University of Chinese Medicine,Beijing 100029,China;Guang′anmen Hospital,China Academy of Chinese Medical Science,Beijing 100053,China)
出处
《世界中医药》
CAS
2021年第9期1422-1426,共5页
World Chinese Medicine
基金
国家自然科学基金项目(81673797)——基于MACC1介导的HGF/WIST1/2通路探讨活血药干预肺癌干细胞血管生成拟态研究。
关键词
甘草泻心汤
放疗
化疗
癌症
口腔溃疡
观察组
对照组
系统评价
Gancao Xiexin Decoction
Radiotherapy
Chemotherapy
Cancer
Mouth ulcers
Test group
Control group
System evaluation
