摘要
目的探讨孕前体质指数(BMI)及妊娠期血糖水平与大于胎龄儿(LGA)发生风险的相关性。方法选取在广东省祈福医院定期产检,完成75 g口服葡萄糖耐量试验(OGTT),并随访至分娩的2035例孕妇的临床资料。采用多因素Logistic回归分析孕前BMI及OGTT不同时间点血糖水平与LGA发生风险的关系。结果统计结果如下:平均孕前BMI(20.2±2.5)kg/m^(2);平均OGTT空腹血糖(4.4±0.4)mmol/L,平均OGTT 1 h血糖(7.9±1.7)mmol/L,平均OGTT 2 h血糖(6.8±1.4)mmol/L;妊娠期糖尿病(GDM)255例(12.5%);LGA 199例(9.8%)。多因素Logistic回归分析显示,OGTT 1 h血糖水平每升高1个单位,LGA发生风险增加1.17倍(OR=1.17;95%CI:1.02~1.32);GDM孕妇分娩新生儿发生LGA的风险是正常孕妇的2.38倍(OR=2.38;95%CI:1.63~3.48),孕前BMI>23.5 kg/m^(2)孕妇较孕前BMI<18.5 kg/m2组孕妇发生LGA的风险显著增加(OR=3.09;95%CI:1.05~9.07)。结论孕前BMI>23.5 kg/m2和妊娠期高血糖是LGA发生的独立危险因素。
Objective To explore the relationship between pre-pregnancy body mass index(BMI)and blood glucose levels during pregnancy and the risk of large for gestational age(LGA).Methods The clinical data of 2035 pregnant women who underwent regular obstetric checkups,completed 75 g oral glucose tolerance test(OGTT),and followed up to delivery in Guangdong clifford hospital were selected.Multivariate Logistic regression was used to analyze the relationship between pre-pregnancy BMI and blood glucose levels at different time points of OGTT and the risk of LGA.Results The statistical results were as follows:average pre-pregnancy BMI(20.2±2.5)kg/m^(2);average OGTT fasting blood glucose(4.4±0.4)mmol/L,average OGTT 1 h blood glucose(7.9±1.7)mmol/L,average OGTT 2 h blood glucose(6.8±1.4)mmol/L;255 cases(12.5%)of gestational diabetes mellitus(GDM);199 cases(9.8%)of LGA.The multivariate Logistic regression analysis showed that for every 1 unit increase in blood glucose level in OGTT 1 hour,the risk of LGA increased by 1.17 times(OR=1.17;95%CI:1.02-1.32);the risk of LGA in newborns of pregnant women with GDM was 2.38 times of that of normal pregnant women(OR=2.38;95%CI:1.63-3.48);the risk of LGA in pregnant women with a BMI of>23.5 kg/m^(2) before pregnancy was significantly higher than that of pregnant women with a BMI of<18.5 kg/m2(OR=3.09;95%CI:1.05-9.07).Conclusion Pre-pregnancy BMI>23.5 kg/m2 and hyperglycemia during pregnancy are independent risk factors for LGA.
作者
蔡文竹
杨美英
莫小跃
CAI Wenzhu;YANG Meiying;MO Xiaoyue(Obstetrics and Gynecology Department,Guangdong Clifford Hospital,Guangzhou 511495,China)
出处
《临床医学研究与实践》
2021年第17期31-33,共3页
Clinical Research and Practice
基金
广州市番禺区科技计划项目(No.2019-Z04-41)。
关键词
孕前体质指数
妊娠期糖尿病
大于胎龄儿
pre-pregnancy body mass index
gestational diabetes mellitus
large for gestational age
