摘要
目的分析ω-3多不饱和脂肪酸(ω-3PUFA)与妊娠期高血压孕妇Th细胞因子水平的关系及对病情进展的预测效能。方法选取2017年2月至2019年4月河北北方学院附属第一医院诊治的120例妊娠期高血压孕妇纳入观察组;另选同期120例规律产检正常孕妇纳入对照组。比较两组血清ω-3PUFA、白介素(IL)-2、IL-10、肿瘤坏死因子(TNF)-α水平,以及IL-2/IL-10和TNF-α/IL-10;采用Pearson相关性分析ω-3PUFA与Th细胞因子的关系;采用受试者操作特征(ROC)曲线下面积(AUC)评价血清ω-3PUFA对病情进展的预测效能。结果观察组血清ω-3PUFA水平明显低于对照组,IL-2/IL-10及TNF-α/IL-10均明显高于对照组,差异均具有统计学意义(P<0.05);两组血清IL-2、IL-10、TNF-α水平比较,差异均无统计学意义(P>0.05);经Pearson相关性分析,妊娠期高血压孕妇血清ω-3PUFA水平与IL-2/IL-10及TNF-α/IL-10均呈负相关(P<0.05);观察组孕妇病情进展26例(21.67%);经ROC曲线分析,血清ω-3PUFA预测妊娠期高血压孕妇病情进展的AUC为0.934,明显高于IL-2/IL-10的0.652和TNF-α/IL-10的0.639,差异具有统计学意义(P<0.05)。结论ω-3PUFA与妊娠期高血压孕妇Th细胞因子平衡密切相关,预测病情进展的效能较好,值得临床进一步研究。
Objective To investigate the relationship between ω-3 polyunsaturated fatty acids(ω-3 PUFA) and Th cytokines and balance in pregnant women with gestational hypertension and its predictive effect on disease progression. Methods 120 pregnant women with gestational hypertension treated in the First Affiliated Hospital of Hebei North University from February 2017 to April 2019 were enrolled in the observation group. 120 normal pregnant women during the same period were selected as control group. The levels of serum ω-3 PUFA, IL-2, IL-10, TNF-α, IL-2/IL-10 and TNF-α/IL-10 were compared between the two groups. Pearson correlation was used to analyze the relationship between ω-3 PUFA and TH cytokines. The area under curve(AUC) of receiver operating characteristic(ROC) was used to evaluate the predictive effect of serum ω-3 PUFA on disease progression. Results Serum ω-3 PUFA level of observation group was significantly lower than control group, IL-2/IL-10 and TNF-α/IL-10 were significantly higher than control group, the differences were statistically significant(P<0.05). There were no significant differences in serum levels of IL-2, IL-10 and TNF-α between the two groups(P>0.05). Pearson correlation analysis showed that serum ω-3 PUFA level was negatively correlated with IL-2/IL-10 and TNF-α/IL-10 in pregnant women with hypertension during pregnancy(P<0.05). All the pregnant women in the observation group had disease progression in 26 cases(21.67%). ROC curve analysis showed that the AUC of serum ω-3 PUFA in predicting the progression of pregnancy hypertension was 0.934, which was significantly higher than that of IL-2/IL-10(0.652) and TNF-α/IL-10(0.639), the difference was statistically significant(P<0.05). Conclusions The ω-3 PUFA is closely related to TH cytokine balance in pregnant women with gestational hypertension, and has a good predictive effect on disease progression, which is worthy of further clinical study.
作者
马春星
刘云春
王思思
王尽轶
贺英
张玉虹
MA Chunxing;LIU Yunchun;WANG Sisi;WANG Jinyi;HE Ying;ZHANG Yuhong(Department of Obstetrics and Gynecology,The First Affiliated Hospital of Hebei North University,Zhangjiakou 075000,Hebei,China)
出处
《中国性科学》
2021年第5期87-91,共5页
Chinese Journal of Human Sexuality
基金
河北省重点研发计划自筹项目(182777232)
张家口市重点研发计划项目(1921027D)。
