摘要
目的分析饮食干预对多囊卵巢综合征患者健康结局的影响。方法计算机检索PubMed、Cochrane Library、Web of Science、Embase、中国生物医学文献数据库、CNKI、万方数据库,纳入关于饮食干预多囊卵巢综合征患者的临床RCT,检索时限截至2020年8月。由2名经过培训的研究员独立筛选文献、提取数据和进行质量评价,并采用RevMan 5.3软件进行Meta分析。结果共纳入9篇临床RCT,总计697例多囊卵巢综合征患者。Meta分析结果显示,与对照组比较,饮食干预能降低多囊卵巢综合征患者的体重(MD=-2.22,95%CI-2.75~-1.68,P<0.001)、BMI(MD=-1.05,95%CI-1.24~-0.87,P<0.001)、腰围(MD=-2.35,95%CI-4.17~-0.53,P=0.01)、空腹血糖(MD=-0.12,95%CI-0.18~-0.05,P<0.001)、空腹胰岛素(MD=-4.77,95%CI-5.59~-3.96,P<0.001)、稳态模型评估胰岛素抵抗指数(MD=-0.93,95%CI-1.29~-0.57,P<0.001)、促黄体生成素(MD=-0.46,95%CI-0.90~-0.03,P=0.040)、促卵泡生成素(MD=-0.16,95%CI-0.31~-0.01,P=0.030)、总睾酮(MD=-0.33,95%CI-0.53~-0.13,P=0.001),提高性激素结合球蛋白(MD=8.02,95%CI 5.55~10.49,P<0.001)和妊娠率(RR=18.38,95%CI 4.47~75.55,P<0.001)。结论饮食干预可提高多囊卵巢综合征患者的妊娠率,改善内分泌代谢状态,降低患者胰岛素抵抗水平和人体可测量指标。
Objective To analyze effects of dietary intervention on health outcome in patients with polycystic ovary syndrome.Methods PubMed,Cochrane Library,Web of Science,Embase,China Biology Medicine disc,CNKI and WanFang Data were searched by the computer,and clinical RCTs about dietary intervention in patients with polycystic ovary syndrome were included.The retrieval time was up to August 2020.Two trained researchers independently screened the literature,extracted data and evaluated the quality.Meta-analysis was performed using RevMan 5.3 software.Results A total of 9 clinical RCTs were included,including 697 patients with polycystic ovary syndrome.The results of Meta-analysis showed that compared with the control group,dietary intervention could reduce the body weight(MD=-2.22,95%CI-2.75--1.68,P<0.001),body mass index(MD=-1.05,95%CI-1.24--0.87,P<0.001),waist circumference(MD=-2.35,95%CI-4.17--0.53,P=0.01),fasting blood glucose(MD=-0.12,95%CI-0.18--0.05,P<0.001),fasting insulin(MD=-4.77,95%CI-5.59--3.96,P<0.001),insulin resistance index assessed by steady-state model(MD=-0.93,95%CI-1.29--0.57,P<0.001),luteinizing hormone(MD=-0.46,95%CI-0.90--0.03,P=0.040),follicle-stimulating hormone(MD=-0.16,95%CI-0.31--0.01,P=0.030),total testosterone(MD=-0.33,95%CI-0.53--0.13,P<0.001),increase sex hormone-binding globulin(MD=8.02,95%CI 5.55-10.49,P<0.001)and pregnancy rate(RR=18.38,95%CI 4.47-75.55,P<0.001)of patients with polycystic ovary syndrome.Conclusions Dietary intervention can improve the pregnancy rate of patients with polycystic ovary syndrome,improve the endocrine and metabolic status and reduce the level of insulin resistance and human measurable indicators.
作者
郭云梅
王连红
刘颖
丁锐
严欣
Guo Yunmei;Wang Lianhong;Liu Ying;Ding Rui;Yan Xin(School of Nursing,Zunyi Medical University,Zunyi 563003,China;Department of Family Planning,Affiliated Hospital of Zunyi Medical University,Zunyi 563003,China)
出处
《中华现代护理杂志》
2021年第16期2134-2141,共8页
Chinese Journal of Modern Nursing
基金
2019年贵州省卫生健康委科学技术基金项目(gzwjkj2019-1-018)
遵义医科大学校级课题黔科合平台人才项目((2017)5733-077)
遵义医科大学研究生科研基金(ZYK023)。
关键词
多囊卵巢综合征
饮食干预
健康状况指标
META分析
Polycystic ovary syndrome
Dietary intervention
Health status indicators
Meta-analysis
