摘要
目的探讨应用维生素K_(1)(Vitamin K_(1),Vit K_(1))和蛇毒血凝酶联合治疗新生儿消化道出血的效果,优选治疗方案。方法将105例消化道出血的新生儿随机分为Vit K_(1)组、蛇毒凝血酶组和联合用药组,每组各35例,均积极治疗原发病。Vit K_(1)组给予Vit K_(1)肌肉注射1 mg;蛇毒凝血酶组给予蛇毒血凝酶注射液静推0.3 U;联合用药组给予Vit K_(1)和蛇毒凝血酶注射液,3 d后观察其止血效果。结果联合用药组总有效率为77.1%,高于Vit K_(1)组(45.7%)和蛇毒凝血酶组(48.6%)(P<0.01)。联合用药组患儿呕血缓解时间、血便缓解时间及便隐血试验转阴时间均小于其他两组(P<0.01)。结论 Vit K1和蛇毒血凝酶联合治疗新生儿消化道出血止血效果显著。
Objective To study the application of Vitamin K_(1)(Vit K_(1)) and snake venom blood clotting enzyme joint for the treatment of neonatal gastrointestinal bleeding, optimal treatment plan. Methods A total of 105 newborns with digestive tract hemorrhage were randomly divided into Vit K_(1) group, the snake venom thrombin group and combination group, each group of 35 cases were actively treating the primary disease. Vit K_(1) group was given intramuscular injection of Vit K_(1) 1 mg;Snake venom thrombin group was given snake venom thrombin injection 0.3 U;Combined treatment group was given Vit K_(1) and snake venom thrombin injection, and the hemostatic effect was observed after 3 d. Results The total effective rate of combined treatment group was 77.1%, which was higher than the Vit K_(1) group(45.7%) and snake venom thrombin group(48.6%)(P<0.01). The remission time of hematemesis, the remission time of blood stool, and the turning negative time of stool occulting blood test in the combined treatment group were all less than those in the other two groups(P<0.01). Conclusion The combined treatment of Vit K_(1) and snake venom blood clotting enzyme has remarkable hemostasis effect on neonatal gastrointestinol bleeding.
作者
孙宏晶
姜春明
付中秋
SUN Hong-jing;JIANG Chun-ming;FU Zhong-qiu(Department of Neonatology,The First Affiliated Hospital of Harbin Medical University,Harbin 150001,China)
出处
《哈尔滨医科大学学报》
CAS
2021年第2期145-147,共3页
Journal of Harbin Medical University
关键词
Vit
K_(1)
蛇毒血凝酶
新生儿
消化道出血
Vit K_(1)
snake venom blood clotting enzyme
the newborn
gastrointestinal bleeding
