摘要
目的探究N-乙酰半胱氨酸联合沙美特罗替卡松粉吸入剂治疗尘肺病患者及对其肺功能及氧化应激的影响。方法 2017年5月—2019年12月选取应急管理部北戴河康复院收治的93例尘肺病患者,简单随机化分组各31例。对照A组予以N-乙酰半胱氨酸治疗,对照B组予以沙美特罗替卡松粉吸入剂治疗,观察组予以N-乙酰半胱氨酸联合沙美特罗替卡松粉吸入剂治疗,3组均治疗6个月。观察对比3组临床疗效、肺功能指标[肺总容量(TLC)、第1 s用力呼气容积(FEV1)及肺活量(VC)]、血气指标[血二氧化碳分压(PaCO2)及动脉氧分压(PaO2)]、氧化应激指标[谷胱甘肽过氧化物酶(GSH-PX)、丙二醛(MDA)、超氧化物歧化酶(SOD)]、胶原代谢指标[基质金属蛋白酶-9(MMP-9)、胶原蛋白-Ⅰ(COL-Ⅰ)、胶原蛋白-Ⅲ(COL-Ⅲ)]水平及不良反应发生率。结果观察组治疗总有效率(93.55%)高于对照A、B组(70.93%、61.29%),差异有统计学意义(P<0.05);治疗3个月、6个月,3组TLC、FEV1、VC均较治疗前提高,且观察组高于对照A、B组,差异均有统计学意义(均P<0.05);治疗3个月、6个月,3组PaCO2、PaO2、GSH-PX、SOD、MDA均较治疗前明显改善,且观察组PaCO2、MDA低于对照A、B组,PaO2、GSH-PX、SOD高于对照A、B组,差异均有统计学意义(均P<0.05);治疗3个月、6个月,3组MMP-9、COL-Ⅰ、COL-Ⅲ均较治疗前下降,且观察组低于对照A、B组,差异均有统计学意义(均P<0.05);3组不良反应发生率相比,差异无统计学意义(P>0.05)。结论 N-乙酰半胱氨酸联合沙美特罗替卡松粉吸入剂治疗尘肺病可显著改善患者肺功能、血气分析、氧化代谢及胶原代谢,进一步提高治疗效果,值得临床推广与应用。
Objective To investigate the effect of N-acetylcysteine combined with salmeterol ticasone powder inhalation on patients with pneumoconiosis and its effect on lung function and oxidative stress. Methods Totally 93 patients with pneumoconiosis admitted in the Emergency General Hospital of Emergency Management Department 2019 were selected from May2017 to December 2019, and grouped by simple randomization, 31 cases in each group. The control group A was treated with Nacetylcysteine, the control group B was treated with salmeterol ticasone powder inhalation, and the observation group was treated with N-acetylcysteine combined with salmeterol ticasone powder inhalation. All three groups were treated for six months. The three groups were observed and compared for the clinical efficacy, lung function indexes[total lung volume(TLC), forced expiratory volume in one second(FEV1) and vital capacity(VC)], blood gas indexes [blood carbon dioxide partial pressure(PaCO2) and arterial oxygen partial pressure(PaO2)], oxidative stress index[glutathione peroxidase(GSH-PX), malondialdehyde(MDA), superoxide dismutase(SOD)], collagen metabolism index[matrix metalloproteinase-9(MMP-9), collagen-Ⅰ(COL-Ⅰ), collagen-Ⅲ(COL-Ⅲ)]levels and the incidence of adverse reactions. Results The total effective rate of treatment in the observation group(93.55%) was higher than that in the control groups A and B, and the difference was statistically significant(P<0.05). After three months and six months of treatment, the TLC, FEV1, and VC of the three groups were higher than those before treatment, and these indexes in observation group were higher than those in the control groups A and B(70.93%,61.29%), and the differences were statistically significant(all P<0.05). After three months and six months of treatment, the PaCO2, PaO2, GSH-PX, SOD and MDA of the three groups were significantly improved compared with before treatment, in addition, PaCO2 and MDA in the observation group were lower than those in the control groups A and B, while PaO2,
作者
魏安银
焦建辉
齐曦明
刘自军
李红梅
WEI An-yin;JIAO Jian-hui;QI Xi-ming;LIU Zi-jun;LI Hong-mei(Pharmacy Department,Beidaihe Rehabilitation Hospital of Emergency Management Department(Beidaihe Sanatorium for Chinese Coal Miners),Qinhuangdao Hebei,066104,China;Pharmacy Department,Emergency General Hospital of Emergency Management Department,Beijing,100028,China;Catheter Room,Emergency General Hospital of Emergency Management Department,Beijing,100028,China;Scientific Research Department of Qinhuangdao First People's Hospital,Qinhuangdao Hebei,066104,China;Laboratory Department,Yinchuan Xingdong Hospital,Yinchuan Ningxia,755100,China)
出处
《职业与健康》
CAS
2021年第5期581-585,共5页
Occupation and Health
基金
秦皇岛市科学技术发展项目(201601B45)。
