摘要
目的 分析汉防己甲素治疗肺尘埃沉着病的效果及对免疫功能的影响。方法 选取2013年12月~2015年12月来我院治疗的70例肺尘埃沉着病患者为研究对象,将患者随机分为两组,每组35例。对照组患者给予矽肺宁治疗,实验患者实施汉防己甲素治疗,比较两组患者的临床疗效、上呼吸道感染及肺部感染发生率、免疫功能指标。结果 对照患者的总有效率为74.29%,显著低于实验组（97.14%）（P〈0.05）。治疗后,实验组患者的CD4明显上升,CD8明显下降,而对照组患者的CD4、CD8较治疗前无显著变化,两组治疗后的CD4、CD8差异有统计学意义（P〈0.05）。对照组患者的上呼吸道感染发生率、肺部感染发生率分别为54.29%、28.57%,显著高于实验组的28.57%、5.71%（P〈0.05）。结论 汉防己甲素治疗肺尘埃沉着病能显著缓解患者的咳嗽、胸痛及气紧症状,改善患者的免疫功能,降低患者的上呼吸道感染、肺部感染发生率。
Objective To evaluate the efficacy of Tetrandrine in the treatment of pulmonary dust disease and its influ- ence on immune function.Methods From December 2013 to December 2015,70 patients with pulmonary dust disease were enrolled in our hospital and divided into control group （n=35） and experimental group （n=35） in random.In the control group,Xifeining Tablets were used,while in the experimental group,Tetrandrine was adopted.The clinical effect, incidence rate of upper respiratory infection and pulmonary infection,and immunity index between two groups were compared.Results In the control group,the total effective rate was 74.29%, and it was much lower than that in the ex- perimental group accounting （97.14%） （P〈0.05）.After therapy,CD4 was greatly increased and CD8 was decreased in the experimental group while in the control group,CD4 and CD8 were not displayed statistical difference compared with be- fore treatment and there was a significant difference of CD4 and CD8 between two groups （P〈0.05）.The incidence rate of upper respiratory infection and pulmonary infection rate was 54.29% and 28.57% respectively,and it was much high- er than those in the experimental group （28.57%,5.71%） （P〈O.O5）.Condusion Tetrandrine in the treatment of pulmonary dust disease can remarkably alleviate cough,chest pain,and shortage of breath of patients,improve immunity function for patients,and decrease the occurrence rate of upper respiratory infection and puhnonary infection.
作者
杨威
YANG Wei(Department of Occupational Diseases,Anshan Occupational Disease Control and Prevention Hospital in Liaoning Province,Anshan 114014,China)
出处
《中国当代医药》
2016年第36期164-166,共3页
China Modern Medicine
关键词
汉防己甲素
肺尘埃沉着病
免疫功能
影响
Tetrandrine
Pulmonary dust disease
Immunity function
Influence
