摘要
microRNA(miRNA)广泛存在多种生物体中。其中,miRNA-34a作为miRNA家族中的一种,在多种心血管疾病中异常表达。本研究从miRNA-34a的概述及心血管相关文献入手,发现miRNA-34a与高血压临床分级呈正相关,参与调节动脉粥样硬化进程,促进斑块形成,而且在缺血再灌注损伤后水平增加,加入抑制剂可改善心室重构,延缓心肌肥厚,同时参与调节心房颤动病理生理过程。这些研究结果提示,miRNA-34a确实与多种常见心血管病密切相关,并可作为这些心血管疾病的诊疗新靶标,为临床预测和诊疗提供借鉴。
microRNA(miRNA)is widely existed in a variety of organisms.As a member of miRNA family,miRNA-34a is abnormally expressed in a variety of cardiovascular diseases.Based on the overview of miRNA-34a and related cardiovascular literature,this study found that miRNA-34a is positively correlated with clinical grade of hypertension,involved in regulating the process of atherosclerosis,promoting plaque formation,and increased after ischemia reperfusion injury.The addition of inhibitors can improve ventricular remodeling and delay cardiac hypertrophy.It also participates in the regulation of the pathophysiological process of atrial fibrillation.These results suggest that miRNA-34a is indeed closely related to a variety of common cardiovascular diseases,and can be used as a new target for the diagnosis and treatment of these cardiovascular diseases,providing reference for clinical prediction and diagnosis and treatment.
作者
刘龙梅
王仲朝
杨霞
王家璞
韩学斌
LIU Long-mei;WANG Zhong-chao;YANG Xia;WANG Jia-pu;HAN Xue-bin(Laboratory,Shanxi Province Cardiovascular Hospital,Shanxi Province,Taiyuan 030024,China;Department of Cardiology,Shanxi Province Cardiovascular Hospital,Shanxi Province,Taiyuan 030024,China)
出处
《中国当代医药》
CAS
2021年第16期32-35,共4页
China Modern Medicine
基金
山西省重点研发计划(指南)项目(201803D421052)
山西省心血管病医院科研激励计划项目(XYS20170204、XYS20190106)。
