摘要
目的探讨慢性阻塞性肺疾病急性加重期(Acute exacerbation of chronic obstructive pulmonary disease,AECOPD)患者血清沉默信息调节因子2相关酶1(Silent information regulator factor 2 related enzyme 1,SIRT1)、内毒素(Endotoxin,ET)水平表达与肺功能的相关性。方法选择2018年2月至2020年2月本院AECOPD患者98例作为研究对象,检测患者的血清SIRT1、ET水平,治疗1疗程后,根据肺功能下降程度分为重度组(n=16)和轻中度组(n=82),比较两组血清SIRT1、ET表达水平,分析血清SIRT1、ET水平对AECOPD患者肺功能的影响与预测价值。结果98例AECOPD患者经治疗后,肺功能重度、极重度下降占比16.33%;对比重度组与轻中度组基线资料发现,重度组SIRT1水平低于对照组,ET、白细胞介素6(Interleukin-6,IL-6)、肿瘤坏死因子α(Tumor necrosis factor-α,TNF-α)水平高于轻中度组(P<0.05);经二元Logistic回归分析后建立多元回归模型,结果显示,血清SIRT1低表达、ET过表达是AECOPD患者肺功能重度下降的影响因素(OR>1,P<0.05);绘制ROC曲线发现,血清SIRT1、ET水平预测AECOPD患者肺功能重度下降风险的AUC分别为:0.885、0.911,均有一定预测价值。结论AECOPD患者血清SIRT1低表达、ET过表达可能提示患者肺功能持续下降,且有重度或极重度下降风险,早期检测AECOPD患者血清SIRT1、ET水平可预测患者肺功能下降程度及风险,对指导早期干预可能有一定应用价值。
Objective To investigate the correlation between the expression of serum silent information regulator 2 related enzyme 1(SIRT1)and endotoxin(ET)and lung function in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods From February 2018 to February 2020,98 patients with AECOPD in our hospital were selected as the research objects.The serum SIRT1 and ET levels of patients were detected.After 1 course of treatment,they were divided into the severe group(n=16)and the mild-moderate group(n=82)according to the degree of lung function decline.The expression of serum SIRT1 and ET levels between the two groups were compared,and the influence and predictive value of serum SIRT1 and ET levels on lung function in AECOPD patients was analyzed.Results After treatment,the lung function of AECOPD patients was severely or extremely decreased,accounting for 16.33%;compared the baseline data between the severe group and the mild-moderate group found that the level of SIRT1 in the severe group was lower than that of the control group,and the levels of ET,interleukin 6(IL-6),and tumor necrosis factor alpha(TNF-α)were higher than those of the mild-moderate group(P<0.05);after binary logistic regression analysis,a multiple regression model was established,and the results showed that the low expression of serum SIRT1 and overexpression of ET were the influencing factors of severe decline of lung function in patients with AECOPD(OR>1,P<0.05);the ROC curve was drawn and found that the serum SIRT1 and ET levels predicted the AUC of the risk of severe lung function decline in AECOPD patients were 0.885 and 0.911 respectively,which had certain predictive value.Conclusion The low expression of serum SIRT1 and overexpression of ET in patients with AECOPD may indicate that the patient′s lung function continues to decline,and there is a risk of severe or extremely severe decline.Early detection of serum SIRT1 and ET levels in AECOPD patients can predict the degree and risk of lung function decline in pati
作者
吴周飞
WU Zhou-fei(Department of Respiratory Medicine,Dengzhou Central Hospital,Nanyang,Henan 474150,China)
出处
《青岛医药卫生》
2021年第3期161-164,共4页
Qingdao Medical Journal
关键词
慢性阻塞性肺疾病
急性加重期
肺功能
血清沉默信息调节因子2相关酶1
内毒素
相关性
Chronic obstructive pulmonary disease
Acute exacerbation period
Lung function
Serum silent information regulator 2 related enzyme 1
Endotoxin
Correlation
