摘要
目的确定复合水合氯醛时右美托咪定用于非紫绀型先天性心脏病患儿CT检查镇静的适宜剂量。方法采用水合氯醛复合右美托咪定镇静下行CT检查的先天性心脏病患儿211例,年龄6月~3岁,性别不限。采用随机数字表法分为3组:D1组(n=69)、D2组(n=71)和D3组(n=71)均口服水合氯醛50 mg/kg,分别右美托咪定1.0、1.5和2.0μg/kg滴鼻。记录患儿药物起效时间、镇静一次成功情况、苏醒时间和不良反应等。结果3组患儿药物起效时间、镇静一次成功率、苏醒时间、心动过缓、呼吸抑制等发生率、镇静后最低心率和最低脉搏血氧饱和度比较差异无统计学意义(P>0.05)。结论非紫绀型先天性心脏病患儿CT检查镇静时推荐口服水合氯醛50 mg/kg复合右美托咪定1.0μg/kg滴鼻,镇静效果确切,对呼吸、循环功能影响小,安全性高。
Objective To determine the optimal dose of dexmedetomidine for sedation when combined with chloral hydrate in pediatric patients with non-cyanotic congenital heart diseases(CHD)undergoing computed tomography(CT).Methods A total of 211 children of both sexes with CHD undergoing CT scan under sedation with chloral hydrate and dexmedetomidine,aged 6 months to 3 yr,were divided into 3 groups using a random number table method:D1 group(n=69),D2 group(n=71)and D3 group(n=71).Chloral hydrate 50 mg/kg was administrated orally,and dexmedetomidine 1.0,1.5 and 2.0μg/kg was administrated intranasally in D1,D2 and D3 groups,respectively.The onset time of drugs,success of sedation at first attempt,time to emergence,and adverse reactions were recorded.Results There were no significant differences in the incidence of onset time of drugs,success rate of sedation at first attempt,emergence time,bradycardia,respiratory depression,and the lowest heart rate after sedation and the lowest pulse oxygen saturation among the three groups(P>0.05).Conclusion For sedation in pediatric patients with non-cyanotic CHD undergoing CT,oral chloral hydrate 50 mg/kg combined with intranasal dexmedetomidine 1.0μg/kg is recommended,and it has a reliable sedative effect and little effect on respiratory and circulatory function with a higher safety.
作者
金立红
黄佳佳
张马忠
Jin Lihong;Huang Jiajia;Zhang Mazhong(Department of Anesthesiology&Pediatric Clinical Pharmacology Laboratory,Shanghai Children′s Medical Center,Shanghai Jiao Tong University School of Medicine,Shanghai 200127,China)
出处
《中华麻醉学杂志》
CAS
CSCD
北大核心
2020年第12期1480-1482,共3页
Chinese Journal of Anesthesiology
基金
上海交通大学医学院2018年度儿科学专业"5+3"一体化培养医学教育研究项目(EKJX2018005DGD)。
