摘要
目的:分析人乳头瘤病毒(human papilloma virus,HPV)感染与宫颈癌发病的相关性。方法:将2018年4月至2019年12月期间在南通市通州区第八人民医院进行体检的1502例南通平潮地区女性作为研究对象。将其中1329例生殖系统良性疾病患者设为对照组。将其中173例宫颈病变患者设为观察组。对两组患者的临床资料进行统计分析,从中找出南通平潮地区女性HPV感染与宫颈癌发病的相关性。结果:观察组患者中宫颈癌前病变为宫颈上皮内瘤变(CIN)1级、CIN2~3级、微小型浸润癌及浸润癌患者HPV的感染率均高于对照组患者,P<0.05。观察组患者中,微小型浸润癌及浸润癌患者HPV的感染率均高于CIN1级及CIN2~3级患者HPV的感染率,P<0.05;宫颈癌前病变为CIN1级、CIN2~3级、微小型浸润癌及浸润癌患者中单一型HPV感染患者的占比均高于多重型HPV感染患者的占比,P<0.05;单一型HPV感染患者及多重型HPV感染患者中高危型HPV感染患者的占比均高于低危型HPV感染患者的占比,P<0.05。进行多因素Logistic回归分析发现,HPV感染和高危型HPV感染均是导致观察组患者宫颈癌发病的独立影响因素。进行Pearson分析发现,HPV感染及高危型HPV感染与宫颈癌的发病呈正相关,P<0.05。结论:发生HPV感染和高危型HPV感染是导致宫颈癌发病的独立影响因素,HPV感染及高危型HPV感染的发生与宫颈癌的发病呈正相关。
Objective:To analyze the correlation between human papilloma virus(HPV)infection and the incidence of cervical cancer.MET HODS:From April 2018 to December 2019,a total of 1502 women in Pingchao District of Nantong who underwent physical examination in the Eighth People’s Hospital of Tongzhou District were selected as subjects.Among them,1329 patients with benign diseases of the reproductive system were set as the control group.Among them,173 patients with cervical lesions were set as the observation group.The clinical data of two groups of patients were statistically analyzed to find out the correlation between HPV infection and the incidence of cervical cancer in women in Pingchao area of Nantong.Results:The rates of HPV infection in cervical precancerous lesions including cervical intraepithelial neoplasia(CIN 1,CIN2~3,micro-invasive carcinoma and invasive carcinoma patients in observation group were higher than those in control group(P<0.05).In the observation group,the HPV infection rate of micro invasive carcinoma and invasive cancer patients was higher than that of CIN1 and CIN2~3 patients,P<0.05;The proportion of cervical precancerous lesions with CIN1 grade,CIN2~3 grade,micro invasive cancer and invasive cancer patients with single type HPV infection were higher than that of patients with multiple severe HPV infection,P<0.05;The proportion of patients with high-risk HPV infection was higher than that of patients with low-risk HPV infection in patients with single HPV infection and patients with multiple severe HPV infection(P<0.05).Multivariate Logistic regression analysis showed that both HPV infection and high-risk HPV infection were independent influencing factors for the incidence of cervical cancer in the observation group.Pearson analysis showed that HPV infection and high-risk HPV infection were positively correlated with the incidence of cervical cancer(P<0.05).Conclusion:The occurrence of HPV infection and high-risk type HPV infection are independent influencing factors leading to the incidence
作者
顾云
陈晓霞
GU Yun;CHEN Xiaoxia(Department of Obstetrics and Gynecology,the Eighth People’s Hospital of Tongzhou District,Nantong 226361)
关键词
人乳头瘤病毒感染
宫颈病变
宫颈癌
相关性
影响因素
human papillomavirus infection
Cervical lesions
Cervical cancer
Correlation
Factors affecting the
