摘要
目的:系统评价埋线疗法治疗顽固性面瘫的有效性。方法:通过检索PubMed、Embase、Cochrane Library数据库、中国生物医学文献数据库(CBM)、知网(CNKI)、维普(VIP)及万方等数据库,收集建库以来至2020年4月30日期间发表的关于埋线疗法治疗顽固性面瘫的相关随机对照试验(RCT),按照纳入、排除标准筛选相关文献,并运用Cochrane偏倚风险评估工具进行文献质量评估,使用RevMen5.3软件进行Meta分析。结果:最终纳入文献10篇,共计845例顽固性面瘫患者。根据纳入研究干预措施的不同,划分为两个亚组:①埋线与单纯针刺比较;②埋线与电针比较。Meta分析结果显示:①对比单纯针刺,埋线治疗顽固性面瘫的总有效率及痊愈率均更优[总有效率RR=1.13,95%CI(1.02,1.26),P=0.03;痊愈率RR=1.58,95%CI(1.06,2.36),P=0.03];②对比电针,埋线治疗顽固性面瘫的总有效率更具优势[RR=1.18,95%CI(1.11,1.25),P<0.00001],但痊愈率不具有同质性(P=0.006,I2=67%),考虑与纳入研究偏移相关。结论:埋线疗法治疗顽固性面瘫的临床疗效优于单纯针刺或电针治疗,但因纳入文献数量不多、质量偏低,需要更多大样本、高质量的随机对照研究进一步验证。
Objective:To systematically evaluate the effectiveness of thread-embedding therapy in the treatment of refractory facial paralysis.Methods:Through searching PubMed,Embase,Cochrane Library database,Chinese Biomedical Literature Database(CBM),CNKI(CNKI),VIP(VIP)and Wanfang and other databases,collecting publications from the establishment of the database to April 30,2020 Relevant randomized controlled trials(RCTs)related to thread-embedding therapy in the treatment of refractory facial paralysis,screened the relevant literature according to the inclusion and exclusion criteria,and used the Cochrane bias risk assessment tool to evaluate the quality of the literature,and the RevMen5.3 software was used for Meta analysis.Results:Finally,10 literature were included,a total of 845 patients with intractable facial paralysis.According to the different intervention measures included in the study,it is divided into two subgroups:①comparison between embedding and simple acupuncture;②comparison between embedding and electroacupuncture.The results of Meta analysis showed that:①Compared with simple acupuncture,the total effective rate and recovery rate of thread embedding in the treatment of refractory facial paralysis were better[total effective rate RR=1.13,95%CI(1.02,1.26),P=0.03;recovery rate RR=1.58,95%CI(1.06,2.36),P=0.03];②Compared with electroacupuncture,the total effective rate of thread embedding in the treatment of refractory facial paralysis is more advantageous[RR=1.18,95%CI(1.11,1.25),P<0.00001],but the recovery rate is not homogeneous(P=0.006,I2=67%),and it is considered to be related to the deviation of the included study.Conclusion:The clinical efficacy of thread-embedding therapy in the treatment of refractory facial paralysis is better than simple acupuncture or electroacupuncture.However,due to the small number of included literature and low quality,more large-sample,highquality randomized controlled studies are needed for further verification.
作者
林万庆
董丹宇
陈斌
谢学敏
LIN Wanqing;DONG Danyu;CHEN Bin;XIE Xuemin(The People’s Hospital of Fujian University of Traditional Chinese Medicine,Fujian Fuzhou 350004,China)
出处
《中医药临床杂志》
2021年第5期913-918,共6页
Clinical Journal of Traditional Chinese Medicine
基金
福建省科技厅引导性项目(2018Y0046)。
关键词
顽固性面瘫
埋线疗法
META分析
Facial paralysis
Intractable
Catgut embedding therapy
Meta-analysis
