摘要
目的探讨清肠愈疡汤治疗溃疡性结肠炎的疗效,以及其对血清肠型脂肪酸结合蛋白(I-FABP)、可溶性晚期糖基化终末产物受体(sRAGE)和D-乳酸(D-LAC)水平的影响。方法选取2018年1月至2020年1月在该院诊断为溃疡性结肠炎的90例患者作为研究对象,根据随机数字法将患者分为观察组和对照组,每组各45例。对照组予以常规治疗,观察组在对照组的基础上予以清肠愈疡汤治疗。观察两组治疗后的疗效和两组治疗前后中医证候评分、疾病活动指数(DAI)、Geboes指数评分、Baron评分、肠道菌群数量、生活质量评分、I-FABP、sRAGE和D-LAC水平变化。结果观察组总有效率为91.11%,对照组总有效率为71.11%,观察组总有效率明显优于对照组,差异有统计学意义(χ2=4.641,P<0.05)。两组治疗后中医证候评分、DAI、Geboes指数评分和Baron评分均较治疗前明显降低,差异有统计学意义(P<0.05)。两组治疗后双歧杆菌和乳酸菌数量较治疗前明显升高(P<0.05)。两组治疗后全身症状、肠道症状、社会能力和情感能力评分均较治疗前明显提高(P<0.05)。两组治疗后血清I-FABP、sRAGE和D-LAC水平均较治疗前明显降低(P<0.05)。结论清肠愈疡汤治疗溃疡性结肠炎疗效显著,能够改善患者肠道炎症、缓解菌群紊乱和提高生活质量,可能与机体血清I-FABP、sRAGE和D-LAC水平降低有关。
Objective To investigate the efficacy of Qingchang Yuyang decoction in the treatment of ulcerative colitis and its effects on serum levels of intestinal fatty acid binding protein(I-FABP),soluble receptor for advanced glycation end products(sRAGE)and D-lactic acid(D-LAC).Methods A total of 90 patients with ulcerative colitis diagnosed in the hospital from January 2018 to January 2020 were enrolled in the study,and were divided into observation group and control group according to random number method,with 45 patients in each group.The control group received conventional treatment,and the observation group was treated with Qingchang Yuyang decoction on the basis of the control group.The efficacy was compared between the two groups after treatment.The scores of TCM symptoms,disease activity index(DAI),Geboes index,Baron score,intestinal flora,quality of life score,I-FABP,sRAGE and D-LAC levels were observe in the two groups before and after treatment.Results The total effective rate of the observation group was 91.11%,the total effective rate of the control group was 71.11%,the total effective rate of the observation group was significantly better than that of the control group,the difference was statistically significant(χ2=4.641,P<0.05).After treatment,TCM syndrome score,DAI,Geboes index score and Baron score in the two groups were significantly lower than those before treatment,with statistical significance(P<0.05).After treatment,the number of bifidobacteria and lactic acid bacteria in both groups was significantly higher than that before treatment(P<0.05).After treatment,the scores of systemic symptoms,intestinal symptoms,social ability and affective ability in both groups were significantly higher than those before treatment(P<0.05).The levels of serum I-FABP,sRAGE and D-LAC in both groups were significantly decreased after treatment compared with before treatment(P<0.05).Conclusion Qingchang Yuyang decoction has significant efficacy in the treatment of ulcerative colitis,which can alleviate intestinal infla
作者
冯欣伟
沈卫萍
王艳
任雪敬
王蓓
FENG Xinwei;SHEN Weiping;WANG Yan;REN Xuejing;WANG Bei△(Department of Gastroenterology,Shanghai Changzheng Hospital,Shanghai 200003,China)
出处
《检验医学与临床》
CAS
2021年第11期1574-1578,共5页
Laboratory Medicine and Clinic
关键词
清肠愈疡汤
溃疡性结肠炎
肠型脂肪酸结合蛋白
可溶性晚期糖基化终末产物受体
D-乳酸
Qingchang Yuyang decoction
ulcerative colitis
intestinal fatty acid binding protein
soluble receptor for advanced glycation end products
D-lactic acid
