摘要
目的探讨非霍奇金淋巴瘤(NHL)患者骨髓涂片中巨噬细胞和噬血细胞计数的临床价值。方法选取NHL初诊患者41例作为观察组,同期的正常骨髓供者20例作为对照组,同期就诊的其他血液系统疾病患者25例作为其他血液疾病组。在油镜下对上述各组骨髓涂片中的巨噬细胞和噬血细胞进行计数,观察组还需同时计数淋巴瘤细胞,以此确定淋巴瘤细胞骨髓浸润程度。根据临床资料对患者进行Ann Arbor分期及分组。用国际预后指数(IPI)评估患者预后。结果观察组的巨噬细胞和噬血细胞计数均高于对照组和其他血液疾病组(P<0.05)。Ann Arbor分期Ⅲ~Ⅳ期的NHL患者巨噬细胞和噬血细胞计数高于Ⅰ~Ⅱ期NHL患者(P<0.05);IPI评分≥2分的NHL患者巨噬细胞和噬血细胞计数高于0~1分的NHL患者(P<0.05);淋巴瘤细胞骨髓浸润程度≥20%的NHL患者巨噬细胞和噬血细胞计数高于浸润程度<3%的NHL患者(P<0.05)。不同性别、不同淋巴瘤病理类型的NHL患者间比较,巨噬细胞和噬血细胞计数差异均无统计学意义(P>0.05)。结论NHL患者骨髓涂片中噬血细胞和巨噬细胞计数与淋巴瘤的发生、进展与预后均有关,并可以作为辅助淋巴瘤诊断的指标。
Objective To investigate the clinical significance of macrophage and hemophagocyte counts in bone marrow smears of patients with non-Hodgkin′s lymphoma(NHL).Methods A total of 41 patients with NHL were enrolled as the observation group,20 normal bone marrow donors were enrolled as the control group,and 25 patients with other blood system diseases were enrolled as the other blood disease group.The macrophages and hemophagocytes in the bone marrow smears of the above groups were counted under oil microscope,and the lymphoma cells in the observation group were counted at the same time,so as to determine the degree of bone marrow infiltration of lymphoma cells.According to the clinical data,the patients were divided into different Ann Arbor stages and groups.The prognosis of the patients was evaluated by international prognostic index(IPI).Results The macrophages and hemophagocytes numbers in the observation group were more than those in the control group and other blood disease groups(P<0.05).The numbers of macrophages and hemophagocytes in NHL patients with Ann Arbor stageⅢ—Ⅳwere more than those in NHL patients with Ann Arbor stageⅠ—Ⅱ(P<0.05).The numbers of macrophages and hemophagocytes in NHL patients with IPI score≥2 were more than those in NHL patients with IPI score 0-1(P<0.05);The numbers of macrophages and hemophagocytes in NHL patients with≥20%lymphoma cell infiltration were more than those in NHL patients with less than 3%lymphoma cell infiltration(P<0.05).There was no significant difference in the numbers of macrophages and hemophagocytes between NHL patients with different gender and pathological types of lymphoma(P>0.05).Conclusion The numbers of hemophagocytes and macrophages in bone marrow smears of NHL patients is related to the occurrence,progression and prognosis of lymphoma,and can be used as an auxiliary diagnostic indicator of lymphoma.
作者
李娜
郭炫
魏绪仓
LI Na;GUO Xuan;WEI Xucang(Department of Clinical Laboratory,Chang′an District Hospital,the First Affiliated Hospital of Xi′an Jiaotong University,Xi′an,Shaanxi 710100,China;Department of Hematology,Shaanxi People′s Hospital,Xi′an,Shaanxi 710068,China)
出处
《检验医学与临床》
CAS
2021年第11期1546-1550,共5页
Laboratory Medicine and Clinic
关键词
非霍奇金淋巴瘤
巨噬细胞
噬血细胞
骨髓涂片
淋巴瘤细胞骨髓浸润程度
non-Hodgkin′s lymphoma
macrophages
hemophagocytes
bone marrow smear
degree of bone marrow infiltration of lymphoma cells
