摘要
目的探讨玻璃酸钠联合重组人表皮生长因子(rhEGF)滴眼液在干眼症病人中的临床效果。方法选取广州医科大学附属惠州医院2018年8月至2019年2月就诊的120例干眼症病例,按随机数字表法分为对照组(n=60,应用0.1%玻璃酸钠滴眼液治疗,4次/天),研究组(n=60,在对照组的基础上加用rhEGF滴眼液治疗,2次/天),均1滴/次,用药6周。比较两组病人治疗效果、肿瘤坏死因子α(TNF-α)和白细胞介素-6(IL-6)水平和泪膜破裂时间(BUT)、泪液分泌长度、眼表疾病指数(OSDI)评分。结果研究组总有效率95.0%(57/60)高于对照组83.3%(50/60)(P<0.05);干预后,研究组病人BUT延长、泪液分泌量增加、OSDI评分降低(P<0.05);研究组干预后,泪液IL-6和TNF-α水平明显低于对照组(P<0.05)。结论玻璃酸钠联合rhEGF滴眼液治疗干眼症临床效果显著。
Objective To investigate the clinical effect of sodium hyaluronate combined with recombinant human epidermal growth factor(rhEGF)eye drops in patients with xerophthalmia.Methods A total of 120 xerophthalmia cases from the Huizhou Hospital affiliated to Guangzhou Medical University from August 2018 to February 2019 were selected.According to a random number table,patients were assigned into a control group(n=60,with 0.1%sodium hyaluronate eye drops for treatment,4 times/day)and the study group(n=60,plus rhEGF eye drops on the basis of the control group,2 times/day),1 drop/time,medication for 6 weeks.The treatment effect,levels of TNF-αand IL-6,tear film burst time(BUT),tear secretion length,and ocular surface disease index(OSDI)scores were compared between the two groups of patients.Results The total effective rate of the study group was 95.0%(57/60)higher than that of the control group 83.3%(50/60)(P<0.05),after the intervention,patients in the study group had prolonged BUT,increased tear secretion,and decreased OSDI score(P<0.05).After the intervention of the study group,the levels of IL-6 and TNF-αin tears were significantly lower than those of the control group(P<0.05).Conclusion Sodium hyaluronate combined with rhEGF eye drops has a significant clinical effect in the treatment of xerophthalmia.
作者
温艳美
程浩
WEN Yanmei;CHENG Hao(Ophthalmology,Guangzhou Medical University Affiliated Huizhou Hospital,Huizhou,Guangdong 516001,China;Ophthalmology,First Affiliated Hospital of Guangzhou Medical University,Guangzhou,Guangdong 510030,China)
出处
《安徽医药》
CAS
2021年第6期1229-1232,共4页
Anhui Medical and Pharmaceutical Journal
基金
广东省科学技术厅公益研究与能力建设专项资金项目(2014A020212365)
