摘要
血浆置换(plasma exchange,PE)是一种用于清除循环中致病性蛋白分子或蛋白结合物质的血液净化手段,已广泛用于临床一些疾病,如自身免疫性疾病的救治中。其技术形式包括膜分离及离心分离2种类型。PE的技术要点包括治疗剂量及频次确定,滤器选择,治疗参数如血流量、血浆分离速度设定,置换液选择,体外循环的抗凝,治疗相关的技术并发症及临床并发症的表现及处理。本文对以上PE技术要点进行了详细阐述,以便临床更好掌握及开展这项技术。
Plasma exchange(PE)is a blood purification method aiming at removing circulating pathogenic proteins or protein-bound substances,which has been widely applied in treating various diseases,including autoimmune diseases.It has two technical forms:membrane separation(MPE)and centrifugal separation(CPE).The technical issues include prescription of treatment dose and frequency,choice of plasma separator,setup of treatment parameters including blood flow rate,plasma separation rate,choice of replacement fluid,anticoagulation,prevention of clinical and technical complications.In this paper,we reviewed all of the issues mentioned above in detail.
作者
朱淑华
龚德华
ZHU Shu-hua;GONG De-hua(National Clinical Research Center of Kidney Diseases,Jinling Hospital,Nanjing University School of Medicine,Nanjing 210002,China)
出处
《中国血液净化》
CSCD
2021年第5期289-293,共5页
Chinese Journal of Blood Purification
基金
国家重点研发项目(2017YFC1104404)。
关键词
血浆置换
治疗剂量
置换液
并发症
Plasma exchange
Dose
Replacement fluid
Complication
