摘要
目的观察益气聪明汤联合西药治疗气血亏虚型恢复期后循环缺血性眩晕的临床疗效。方法将110例气血亏虚型恢复期后循环缺血性眩晕患者随机分为治疗组和对照组,每组55例。对照组予阿司匹林和盐酸氟桂利嗪治疗,治疗组在对照组治疗措施基础上加用益气聪明汤。两组疗程均为28 d,观察临床疗效,比较中医证候积分、经颅多普勒超声脑血流指标的变化情况,同时进行安全性评价。结果 (1)治疗组、对照组的愈显率分别为94.5%、50.9%,治疗组临床疗效优于对照组(P<0.01)。(2)治疗前后组内比较,两组中医证候积分均降低(P<0.01);组间治疗后比较,治疗组中医证候积分低于对照组(P<0.01)。(3)治疗前后组内比较,两组左椎动脉、右椎动脉、基底动脉的平均血流速度和搏动指数差异有统计学意义(P<0.01);组间治疗后比较,上述指标差异均有统计学意义(P<0.05)。(4)治疗组、对照组的不良反应发生率分别为16.3%、18.2%,差异无统计学意义(P>0.05)。结论与单纯采用西药相比,加用益气聪明汤治疗气血亏虚型恢复期后循环缺血性眩晕疗效满意,能更好地改善患者的临床症状,其作用机制可能与增加椎-基底动脉系统的血液灌注有关。
Objective To observe the clinical effect of Yiqi Congming Decoction combined with western medicine on posterior circulation ischemic vertigo(PCIV) of qi and blood deficiency syndrome in recovery period. Methods A total of 110 PCIV cases of qi and blood deficiency syndrome in recovery period were randomly divided into treatment group(n=55) and control group(n=55). The control group was administered with aspirin and flunarizine hydrochloride, while the treatment group was administered with Yiqi Congming Decoction besides the conventional treatment of the control group. The course of treatment in both groups was 28 days. The clinical effect was observed, the changes of TCM syndrome scores and transcranial Doppler ultrasound(TCDU) cerebral blood flow indexes(CBFI) were compared, and the safety was evaluated simultaneously. Result(1)The cured and markedly effective rate of the treatment group and the control group were 94.5% and 50.9%, respectively. The clinical effect of the treatment group was better than that of the control group(P<0.01).(2)The TCM symptom scores in both groups decreased after treatment(P<0.01);The TCM syndrome score in the treatment group was lower than that in the control group after treatment(P<0.01).(3)The mean blood flow velocity and pulsatility index of left vertebral artery, right vertebral artery and basilar artery in the two groups were significantly different before and after treatment(P<0.01). After treatment, the above indexes were significantly different between the groups(P<0.05).(4)The incidence of adverse reactions in the treatment group and the control group were 16.3% and 18.2% respectively, with no significant difference(P>0.05). Conclusion Compared with the single use of western medicine, the combined use of Yiqi Congming Decoction with western medicine has more satisfactory curative effect on PCIV of qi and blood deficiency syndrome in recovery period, and can better improve patients’ clinical symptoms. The mechanism of action may be related to increasing hemoperfusion of ver
作者
亓光峰
赵超蓉
QI Guangfeng;ZHAO Chaorong(Department of Encephalopathy,Shanghai Putuo District Hospital of Traditional Chinese Medicine,Shanghai 200062,China)
出处
《上海中医药杂志》
2021年第4期60-62,91,共4页
Shanghai Journal of Traditional Chinese Medicine
基金
上海市卫计委进一步加快中医药事业发展三年行动计划项目(ZY3-JSFC-1-1013)。
关键词
后循环缺血
眩晕
恢复期
益气聪明汤
气血亏虚
posterior circulation ischemia
vertigo
recovery period
Yiqi Congming Decoction
qi and blood deficiency
