摘要
目的研究分析血清胱抑素C(Cys-C)、同型半胱氨酸(Hcy)、甘油三酯/高密度脂蛋白胆固醇(TG/HDL-C)比值联合检测对老年冠心病的诊断价值。方法前瞻性选取于2016年1月至2018年12月武汉市红十字会医院行冠脉造影确诊的120例老年冠心病患者作为观察组,并选取同期行健康体检的115位体检人员作为对照组。比较2组对象Hcy、Cys-C、血脂各项指标水平,并分析血清Cys-C、Hcy、TG/HDL-C比值单项及联合检测诊断冠心病的价值。结果观察组冠心病患者血清Hcy、Cys-C水平为(14.81±4.69)μmol/L、(1.49±0.31)μg/L,明显高于对照组[(5.69±2.33)μmol/L、(0.51±0.09)μg/L],差异均有统计学意义(P<0.05)。观察组冠心病患者TG、TC以及LDL-C水平为(1.89±0.54)、(5.05±0.94)、(2.88±0.69)mmol/L,明显高于对照组[(1.52±0.41)、(4.71±0.95)、(2.48±0.71)mmol/L],HDL-C、TG/HDL-C比值为(2.06±0.22)mmol/L、1.09±0.71,明显低于对照组[(2.44±0.19)mmol/L、1.61±0.69],差异均有统计学意义(P<0.05)。血清Cys-C、Hcy、TG/HDL-C比值联合检测的诊断价值明显高于血清Cys-C、Hcy、TG/HDL-C比值单项检测(P<0.05)。结论与健康人相比,冠心病患者血清Hcy、Cys-C、TG、TC、LDL-C、TG/HDL-C比值水平出现异常表达,且Cys-C、Hcy、TG/HDL-C比值联合检测有利于老年冠心病的诊断价值,其联合检测准确率高于单项指标检测,值得在临床上广泛推广。
Objective To study and analyze the diagnostic value of combined examination of serum Cystatin C(Cys-C),homocysteine(Hcy),triglyceride/high-density lipoprotein cholesterol(TG/HDL-C)ratio in the diagnosis of senile coronary heart disease.Methods From January 2016 to December 2018,120 patients with senile coronary artery disease diagnosed by coronary angiography in Wuhan Red Cross Hospital were prospectively selected as the observation group,and 115 medical examiners who underwent health examinations during the same period were selected as the control group.The levels of Hcy,Cys-C,and blood lipids of the two groups of subjects were compared,and the value of the single line of serum Cys-C,Hcy,TG/HDL-C ratio and the combined diagnosis of coronary heart disease were analyzed.Results The levels of serum Hcy and Cys-C in patients with coronary heart disease in the observation group were(14.81±4.69)μmol/L and(1.49±0.31)μg/L,which were significantly higher than those in the healthy control group[(5.69±2.33)μmol/L,(0.51±0.09)μg/L],the differences were statistically significant(P<0.05).The levels of TG,TC and LDL-C in patients with coronary heart disease in the observation group were(1.89±0.54),(5.05±0.94),(2.88±0.69)mmol/L,which were significantly higher than those in the control group[(1.52±0.41),(4.71±0.95),(2.48±0.71)mmol/L],HDL-C,TG/HDL-C ratios were(2.06±0.22)mmol/L,1.09±0.71,which were significantly lower than those in the control group[(2.44±0.19)mmol/L,1.61±0.69],the differences were statistically significant(P<0.05).The diagnostic value of serum Cys-C,Hcy combined with TG/HDL-C ratio test was significantly higher than that of serum Cys-C,Hcy,TG/HDL-C ratio single test(P<0.05).Conclusion Compared with healthy people,the serum Hcy,Cys-C,TG,TC,LDL-C,TG/HDL-C ratio levels in senile coronary heart disease are abnormal,and the combined detection of Cys-C,Hcy,TG/HDL-C ratio is beneficial to the diagnostic value of elderly coronary heart disease.The detection accuracy is high and it is worthy of being wid
作者
王黎
韩泉
谢丹
WANG Li;HAN Quan;XIE Dan(Department of Internal Medicine,Wuhan Red Cross Hospital,Wuhan Hubei 430015,China.)
出处
《临床和实验医学杂志》
2021年第9期931-934,共4页
Journal of Clinical and Experimental Medicine
基金
湖北省卫生厅科研项目(编号:JX6B99)。
