摘要
目的探讨血脂6项、总胆固醇(TC)与高密度脂蛋白胆固醇(HDL-C)比值(TC/HDL-C)及残余胆固醇(RC)在老年肺血栓栓塞症(PTE)患者中的诊断鉴别价值。方法选取该院2019年1月至2023年2月收治的116例PTE患者作为PTE组,109例动脉粥样硬化(AS)患者作为AS组,以及116例体检健康者作为对照组。比较3组基本资料及血脂相关指标水平差异,采用受试者工作特征(ROC)曲线和多因素Logistic回归分析考察其在疾病中的诊断价值和鉴别性能。结果与对照组比较,PTE组TC、HDL-C、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白(Apo)A1水平较低,TC/HDL-C、RC水平较高(P<0.05);与AS组比较,PTE组HDL-C、ApoA1、ApoB水平较低,TC/HDL-C、RC水平较高(P<0.05)。ROC曲线和多因素Logistic回归分析显示,HDL-C[曲线下面积(AUC)为0.752,OR为0.028]、ApoA1(AUC为0.824,OR为0.003)在PTE患者中具有较好诊断性能;HDL-C(AUC为0.761,OR为0.060)、ApoA1(AUC为0.778,OR为0.015)、TC/HDL-C(AUC为0.730,OR为3.578)在PTE患者中具有较好鉴别性能。ApoA1和TC/HDL-C联合诊断的AUC为0.842,鉴别诊断的AUC为0.803。结论血脂相关指标在PTE患者中具有特征性表现,HDL-C、ApoA1和ApoA1联合TC/HDL-C可用于老年PTE患者诊断及鉴别诊断。
Objective To investigate the differential diagnostic value of six serum lipids,total cholesterol(TC)to high-density lipoprotein cholesterol(HDL-C)ratio(TC/HDL-C)and residual cholesterol(RC)in elderly patients with pulmonary thromboembolism(PTE).Methods A total of 116 PTE patients admitted to the hospital from January 2019 to February 2023 were selected as PTE group,109 atherosclerosis of the arteries(AS)patients were selected as AS group,and 116 healthy people were selected as control group.The basic data and blood lipid related indexes were compared among the three groups.Receiver operating characteristic(ROC)curve and multivariate Logistic regression analysis were used to evaluate the diagnostic value and differential performance of these markers.Results Compared with the control group,the levels of TC,HDL-C,low-density lipoprotein cholesterol(LDL-C)and apolipoprotein(Apo)A1 in PTE group were lower,and the levels of TC/HDL-C and RC were higher(P<0.05).Compared with AS group,the levels of HDL-C,ApoA1 and ApoB were significantly lower,and the levels of TC/HDL-C and RC were significantly higher in PTE group(P<0.05).ROC curve and multivariate Logistic regression analysis showed that HDL-C[area under curve(AUC)=0.752,OR=0.028]and ApoA1(AUC=0.824,OR=0.003)had better diagnostic performance in PTE patients.HDL-C(AUC=0.761,OR=0.060),ApoA1(AUC=0.778,OR=0.015),TC/HDL-C(AUC=0.730,OR=3.578)had good discrimination performance in PTE patients.The AUC of combined diagnosis of ApoA1 and TC/HDL-C ratio was 0.842,and the AUC of differential diagnosis was 0.803.Conclusion HDL-C,ApoA1 and ApoA1 combined with TC/HDL-C could be used for the diagnosis and differential diagnosis of PTE in elderly patients.
作者
韩冰清
达娃拉姆
王玉飞
刘杰
张国军
HAN Bingqing;DAWA Lamu;WANG Yufei;LIU Jie;ZHANG Guojun(Laboratory Diagnosis Center,Beijing Tiantan Hospital,Capital Medical University/Beijing Engineering Research Center of Immunological Reagents Clinical Research/NMPA Key Laboratory for Quality Control of In Vitro Diagnostics,Beijing 100070,China;Department of Clinical Laboratory Diagnosis,Capital Medical University,Beijing,100070,China)
出处
《国际检验医学杂志》
CAS
2023年第23期2822-2826,共5页
International Journal of Laboratory Medicine
基金
北京市高层次公共卫生技术人才建设项目(学科带头人-01-13)。
关键词
血脂
肺血栓栓塞症
动脉粥样硬化
blood lipid
pulmonary thromboembolism
atherosclerosis of the arteries
